Abstract
Antioxidant nutrients and carotenoids have been inconsistently associated with ovarian cancer risk. We examined the relationship between intake of dietary and supplemental antioxidant nutrients including vitamins C, E, and selenium as well as carotenoids and vitamin A and ovarian cancer in 133,614 postmenopausal women enrolled in the Women's Health Initiative (WHI) study. Dietary intake was assessed using a food frequency questionnaire, and ovarian cancer endpoints were centrally adjudicated. Cox regression models were used to estimate the risk for invasive ovarian cancer in relation to each of the antioxidant nutrients and carotenoids under consideration using models stratified for a WHI study component. A total of 451 cases of invasive ovarian cancer were diagnosed over 8.3 yr of follow-up. Dietary intake at baseline was not significantly different for cases vs. controls. Cases reported greater intake of supplemental vitamin C (358.0 mg/day vs. 291.6 mg/day, respectively; P = 0.024). Multivariate modeling (P for trend) of the risk for developing ovarian cancer did not suggest any significant relationships among dietary factors and ovarian cancer risk. The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 710-719 |
| Number of pages | 10 |
| Journal | Nutrition and Cancer |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2008 |
Fingerprint
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Oncology
- Cancer Research
Cite this
The role of antioxidants and vitamin A in ovarian cancer : Results from the women's health initiative. / Thomson, Cynthia; Neuhouser, Marian L.; Shikany, James M.; Caan, Bette J.; Monk, Bradley J.; Mossavar-Rahmani, Yasmin; Sarto, Gloria; Parker, Linda M.; Modugno, Francesmary; Anderson, Garnet L.
In: Nutrition and Cancer, Vol. 60, No. 6, 11.2008, p. 710-719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of antioxidants and vitamin A in ovarian cancer
T2 - Results from the women's health initiative
AU - Thomson, Cynthia
AU - Neuhouser, Marian L.
AU - Shikany, James M.
AU - Caan, Bette J.
AU - Monk, Bradley J.
AU - Mossavar-Rahmani, Yasmin
AU - Sarto, Gloria
AU - Parker, Linda M.
AU - Modugno, Francesmary
AU - Anderson, Garnet L.
PY - 2008/11
Y1 - 2008/11
N2 - Antioxidant nutrients and carotenoids have been inconsistently associated with ovarian cancer risk. We examined the relationship between intake of dietary and supplemental antioxidant nutrients including vitamins C, E, and selenium as well as carotenoids and vitamin A and ovarian cancer in 133,614 postmenopausal women enrolled in the Women's Health Initiative (WHI) study. Dietary intake was assessed using a food frequency questionnaire, and ovarian cancer endpoints were centrally adjudicated. Cox regression models were used to estimate the risk for invasive ovarian cancer in relation to each of the antioxidant nutrients and carotenoids under consideration using models stratified for a WHI study component. A total of 451 cases of invasive ovarian cancer were diagnosed over 8.3 yr of follow-up. Dietary intake at baseline was not significantly different for cases vs. controls. Cases reported greater intake of supplemental vitamin C (358.0 mg/day vs. 291.6 mg/day, respectively; P = 0.024). Multivariate modeling (P for trend) of the risk for developing ovarian cancer did not suggest any significant relationships among dietary factors and ovarian cancer risk. The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk.
AB - Antioxidant nutrients and carotenoids have been inconsistently associated with ovarian cancer risk. We examined the relationship between intake of dietary and supplemental antioxidant nutrients including vitamins C, E, and selenium as well as carotenoids and vitamin A and ovarian cancer in 133,614 postmenopausal women enrolled in the Women's Health Initiative (WHI) study. Dietary intake was assessed using a food frequency questionnaire, and ovarian cancer endpoints were centrally adjudicated. Cox regression models were used to estimate the risk for invasive ovarian cancer in relation to each of the antioxidant nutrients and carotenoids under consideration using models stratified for a WHI study component. A total of 451 cases of invasive ovarian cancer were diagnosed over 8.3 yr of follow-up. Dietary intake at baseline was not significantly different for cases vs. controls. Cases reported greater intake of supplemental vitamin C (358.0 mg/day vs. 291.6 mg/day, respectively; P = 0.024). Multivariate modeling (P for trend) of the risk for developing ovarian cancer did not suggest any significant relationships among dietary factors and ovarian cancer risk. The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk.
UR - http://www.scopus.com/inward/record.url?scp=56249100703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56249100703&partnerID=8YFLogxK
U2 - 10.1080/01635580802233983
DO - 10.1080/01635580802233983
M3 - Article
C2 - 19005970
AN - SCOPUS:56249100703
VL - 60
SP - 710
EP - 719
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 6
ER -