The role of antiphospholipid antibodies in stroke

Bruce M Coull, S. R. Levine, R. L. Brey

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Antiphospholipid antibodies may be found in about 10% of all subjects with acute stroke but probably are present in as many as 50% of young persons with stroke and perhaps even in high prevalence in persons who have coexisting rheumatologic diseases such as SLE. In these latter groups, the association may be as high as 50%. Probably the best related syndrome is Sneddon's syndrome, which has a high predilection to dementia. Furthermore, vascular dementia may be a prominent feature of the aPL syndrome in subjects under age 55. The cause and mechanism by which aPL are related to stroke remain unknown. Likewise, there is a dearth of information about prognosis, morbidity, and stroke recurrence in subjects who have these immunoglobulin markers. Thus therapy remains very problematic, but current strategies include the use of antiaggregate therapy, warfarin, and limited implementation with prednisone and plasmaphoresis. Data that demonstrate clear cut benefit of any of these therapies are lacking. Ultimately, unraveling these crucial problems concerning the aPL syndrome may provide great insight into certain stroke mechanisms.

Original languageEnglish (US)
Pages (from-to)125-143
Number of pages19
JournalNeurologic Clinics
Volume10
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Antiphospholipid Antibodies
Stroke
Sneddon Syndrome
Vascular Dementia
Warfarin
Prednisone
Dementia
Immunoglobulins
Therapeutics
Morbidity
Recurrence

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Coull, B. M., Levine, S. R., & Brey, R. L. (1992). The role of antiphospholipid antibodies in stroke. Neurologic Clinics, 10(1), 125-143.

The role of antiphospholipid antibodies in stroke. / Coull, Bruce M; Levine, S. R.; Brey, R. L.

In: Neurologic Clinics, Vol. 10, No. 1, 1992, p. 125-143.

Research output: Contribution to journalArticle

Coull, BM, Levine, SR & Brey, RL 1992, 'The role of antiphospholipid antibodies in stroke', Neurologic Clinics, vol. 10, no. 1, pp. 125-143.
Coull, Bruce M ; Levine, S. R. ; Brey, R. L. / The role of antiphospholipid antibodies in stroke. In: Neurologic Clinics. 1992 ; Vol. 10, No. 1. pp. 125-143.
@article{183a95911bdc49b0a9cec23799dca928,
title = "The role of antiphospholipid antibodies in stroke",
abstract = "Antiphospholipid antibodies may be found in about 10{\%} of all subjects with acute stroke but probably are present in as many as 50{\%} of young persons with stroke and perhaps even in high prevalence in persons who have coexisting rheumatologic diseases such as SLE. In these latter groups, the association may be as high as 50{\%}. Probably the best related syndrome is Sneddon's syndrome, which has a high predilection to dementia. Furthermore, vascular dementia may be a prominent feature of the aPL syndrome in subjects under age 55. The cause and mechanism by which aPL are related to stroke remain unknown. Likewise, there is a dearth of information about prognosis, morbidity, and stroke recurrence in subjects who have these immunoglobulin markers. Thus therapy remains very problematic, but current strategies include the use of antiaggregate therapy, warfarin, and limited implementation with prednisone and plasmaphoresis. Data that demonstrate clear cut benefit of any of these therapies are lacking. Ultimately, unraveling these crucial problems concerning the aPL syndrome may provide great insight into certain stroke mechanisms.",
author = "Coull, {Bruce M} and Levine, {S. R.} and Brey, {R. L.}",
year = "1992",
language = "English (US)",
volume = "10",
pages = "125--143",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The role of antiphospholipid antibodies in stroke

AU - Coull, Bruce M

AU - Levine, S. R.

AU - Brey, R. L.

PY - 1992

Y1 - 1992

N2 - Antiphospholipid antibodies may be found in about 10% of all subjects with acute stroke but probably are present in as many as 50% of young persons with stroke and perhaps even in high prevalence in persons who have coexisting rheumatologic diseases such as SLE. In these latter groups, the association may be as high as 50%. Probably the best related syndrome is Sneddon's syndrome, which has a high predilection to dementia. Furthermore, vascular dementia may be a prominent feature of the aPL syndrome in subjects under age 55. The cause and mechanism by which aPL are related to stroke remain unknown. Likewise, there is a dearth of information about prognosis, morbidity, and stroke recurrence in subjects who have these immunoglobulin markers. Thus therapy remains very problematic, but current strategies include the use of antiaggregate therapy, warfarin, and limited implementation with prednisone and plasmaphoresis. Data that demonstrate clear cut benefit of any of these therapies are lacking. Ultimately, unraveling these crucial problems concerning the aPL syndrome may provide great insight into certain stroke mechanisms.

AB - Antiphospholipid antibodies may be found in about 10% of all subjects with acute stroke but probably are present in as many as 50% of young persons with stroke and perhaps even in high prevalence in persons who have coexisting rheumatologic diseases such as SLE. In these latter groups, the association may be as high as 50%. Probably the best related syndrome is Sneddon's syndrome, which has a high predilection to dementia. Furthermore, vascular dementia may be a prominent feature of the aPL syndrome in subjects under age 55. The cause and mechanism by which aPL are related to stroke remain unknown. Likewise, there is a dearth of information about prognosis, morbidity, and stroke recurrence in subjects who have these immunoglobulin markers. Thus therapy remains very problematic, but current strategies include the use of antiaggregate therapy, warfarin, and limited implementation with prednisone and plasmaphoresis. Data that demonstrate clear cut benefit of any of these therapies are lacking. Ultimately, unraveling these crucial problems concerning the aPL syndrome may provide great insight into certain stroke mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0026578836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026578836&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 125

EP - 143

JO - Neurologic Clinics

JF - Neurologic Clinics

SN - 0733-8619

IS - 1

ER -