The role of b cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice

Robert A. Eisenberg, Eric S. Sobel, Elizabeth A. Reap, Melissa D. Halpern, Philip L. Cohen

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalSeminars in Immunology
Volume6
Issue number1
DOIs
StatePublished - Feb 1994

Keywords

  • B cells
  • Chimera
  • Gld
  • Lpr
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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