Abstract
Keeping a delicate balance in the immune system by eliminating invading pathogens, while still maintaining self-tolerance to avoid autoimmunity, is critical for the body's health. The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Here we review the advances in our understanding of how the gut microbiota regulates innate and adaptive immune homeostasis, which in turn can affect the development of not only intestinal but also systemic autoimmune diseases. Exploring the interaction of gut microbes and the host immune system will not only allow us to understand the pathogenesis of autoimmune diseases but will also provide us new foundations for the design of novel immuno- or microbe-based therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4-14 |
| Number of pages | 11 |
| Journal | Gut Microbes |
| Volume | 3 |
| Issue number | 1 |
| State | Published - Jan 2012 |
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ASJC Scopus subject areas
- Gastroenterology
- Infectious Diseases
- Microbiology (medical)
- Microbiology
Cite this
The role of gut microbiota in immune homeostasis and autoimmunity. / Wu, Hsin Jung; Wu, Eric.
In: Gut Microbes, Vol. 3, No. 1, 01.2012, p. 4-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of gut microbiota in immune homeostasis and autoimmunity.
AU - Wu, Hsin Jung
AU - Wu, Eric
PY - 2012/1
Y1 - 2012/1
N2 - Keeping a delicate balance in the immune system by eliminating invading pathogens, while still maintaining self-tolerance to avoid autoimmunity, is critical for the body's health. The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Here we review the advances in our understanding of how the gut microbiota regulates innate and adaptive immune homeostasis, which in turn can affect the development of not only intestinal but also systemic autoimmune diseases. Exploring the interaction of gut microbes and the host immune system will not only allow us to understand the pathogenesis of autoimmune diseases but will also provide us new foundations for the design of novel immuno- or microbe-based therapies.
AB - Keeping a delicate balance in the immune system by eliminating invading pathogens, while still maintaining self-tolerance to avoid autoimmunity, is critical for the body's health. The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Here we review the advances in our understanding of how the gut microbiota regulates innate and adaptive immune homeostasis, which in turn can affect the development of not only intestinal but also systemic autoimmune diseases. Exploring the interaction of gut microbes and the host immune system will not only allow us to understand the pathogenesis of autoimmune diseases but will also provide us new foundations for the design of novel immuno- or microbe-based therapies.
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UR - http://www.scopus.com/inward/citedby.url?scp=84865288138&partnerID=8YFLogxK
M3 - Article
C2 - 22356853
VL - 3
SP - 4
EP - 14
JO - Gut Microbes
JF - Gut Microbes
SN - 1949-0976
IS - 1
ER -