The role of innate immunity in asthma development and protection: Lessons from the environment

Vadim Pivniouk, Joao Antonio Gimenes Junior, Linnea K. Honeker, Donata Vercelli

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalClinical and Experimental Allergy
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • asthma
  • environment
  • farm effect
  • hygiene hypothesis
  • innate immunity
  • microbiome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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