The role of JAGGED in shaping lateral organs

José R. Dinneny, Ramin Yadegari, Robert L. Fischer, Martin F. Yanofsky, Detlef Weigel

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

Position-dependent regulation of growth is important for shaping organs in multicellular organisms. We have characterized the role of JAGGED, a gene that encodes a protein with a single C2H2 zinc-finger domain, in controlling the morphogenesis of lateral organs in Arabidopsis thaliana. Loss of JAGGED function causes organs to have serrated margins. In leaves, the blade region is most severely affected. In sepals, petals and stamens, the strongest defects are seen in the distal regions. By monitoring cell-cycle activity in developing petals with the expression of HISTONE 4, we show that JAGGED suppresses the premature differentiation of tissues, which is necessary for the formation of the distal region. The localization of defects overlaps with the expression domain of JAGGED, which is restricted to the growing regions of lateral organs. JAGGED expression is notably absent from the cryptic bract, the remnant of a leaf-like organ that subtends the flower in many species but does not normally develop in wild-type Arabidopsis. If misexpressed, JAGGED can induce the formation of bracts, suggesting that the exclusion of JAGGED from the cryptic bract is a cause of bractless flowers in Arabidopsis.

Original languageEnglish (US)
Pages (from-to)1101-1110
Number of pages10
JournalDevelopment
Volume131
Issue number5
DOIs
StatePublished - Mar 2004

Fingerprint

Arabidopsis
Morphogenesis
Cell Cycle
Growth
Genes
Proteins

Keywords

  • APETALA1
  • Arabidopsis thaliana
  • Bract development
  • Flower development
  • JAGGED
  • Leaf development

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Dinneny, J. R., Yadegari, R., Fischer, R. L., Yanofsky, M. F., & Weigel, D. (2004). The role of JAGGED in shaping lateral organs. Development, 131(5), 1101-1110. https://doi.org/10.1242/dev.00949

The role of JAGGED in shaping lateral organs. / Dinneny, José R.; Yadegari, Ramin; Fischer, Robert L.; Yanofsky, Martin F.; Weigel, Detlef.

In: Development, Vol. 131, No. 5, 03.2004, p. 1101-1110.

Research output: Contribution to journalArticle

Dinneny, JR, Yadegari, R, Fischer, RL, Yanofsky, MF & Weigel, D 2004, 'The role of JAGGED in shaping lateral organs', Development, vol. 131, no. 5, pp. 1101-1110. https://doi.org/10.1242/dev.00949
Dinneny JR, Yadegari R, Fischer RL, Yanofsky MF, Weigel D. The role of JAGGED in shaping lateral organs. Development. 2004 Mar;131(5):1101-1110. https://doi.org/10.1242/dev.00949
Dinneny, José R. ; Yadegari, Ramin ; Fischer, Robert L. ; Yanofsky, Martin F. ; Weigel, Detlef. / The role of JAGGED in shaping lateral organs. In: Development. 2004 ; Vol. 131, No. 5. pp. 1101-1110.
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