The role of mhc polymorphism in anti-microbial resistance

Janko Nikolich-Žugich, Daved H. Fremont, Michael J. Miley, Ilhem Messaoudi

Research output: Contribution to journalShort survey

43 Scopus citations

Abstract

The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.

Original languageEnglish (US)
Pages (from-to)501-512
Number of pages12
JournalMicrobes and Infection
Volume6
Issue number5
DOIs
StatePublished - Apr 2004
Externally publishedYes

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Keywords

  • Bm
  • CDR regions
  • CTL
  • Complementarity-determining region of the TCR
  • Cytotoxic T lymphocytes
  • Dm
  • Immunity
  • MHC
  • Mhc mutation arising in the murine H-2 haplotype
  • Pathogen resistance
  • T-cell receptor

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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