The role of nitric oxide synthase/nitric oxide in vascular smooth muscle control

D. Bradford Sanders, Tara Kelley, Douglas F Larson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Vascular compliance is dependent on endogenous and exogenous sources of nitric-oxide (NO). In a discussion of therapeutics and NO derived via nitric oxide synthase (NOS) enzymes, it is necessary to examine the pathways of each drug to provide the clinical perfusionist with a greater understanding of the role of NOS/NO in vascular function. Endothelial-derived NO is a contributor in the vasoregulation of vascular smooth muscle. Therapeutics seek to mimic the vasodilatory effects of the endogenous NO. The therapeutics included in this review are nitroglycerin, nitroprusside, amyl nitrite, and inhalation of NO. L-Arginine supplementation provides additional substrate for the endogenous pathway that can augment NO production. NO is a small bioactive molecule involved in various biochemical pathways. Dysregulation of NO production can impair normal physiologic control of vascular compliance. Therefore, the purpose of this review is to provide the perfusionist with an understanding of the biochemical and pharmacological aspects of NOS/NO associated with vascular function.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalPerfusion
Volume15
Issue number2
StatePublished - 2000

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Nitric oxide
Vascular Smooth Muscle
Nitric Oxide Synthase
Muscle
Nitric Oxide
Blood Vessels
drug
Compliance
Amyl Nitrite
Nitroglycerin
Nitroprusside
Arginine
Inhalation
Therapeutics
Pharmacology
Enzymes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The role of nitric oxide synthase/nitric oxide in vascular smooth muscle control. / Sanders, D. Bradford; Kelley, Tara; Larson, Douglas F.

In: Perfusion, Vol. 15, No. 2, 2000, p. 97-104.

Research output: Contribution to journalArticle

Sanders, D. Bradford ; Kelley, Tara ; Larson, Douglas F. / The role of nitric oxide synthase/nitric oxide in vascular smooth muscle control. In: Perfusion. 2000 ; Vol. 15, No. 2. pp. 97-104.
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