The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng, Chenzhen Du, Peiyang Song, Tianyi Chen, Shunli Rui, David G. Armstrong, Wuquan Deng

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.

Original languageEnglish (US)
Article number8852759
JournalOxidative Medicine and Cellular Longevity
Volume2021
DOIs
StatePublished - 2021
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

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