The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

Tracy A. Brooks, Laurence Hurley

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

MYC is deregulated in most tumour types, but an effective means to selectively target its aberrant expression is not yet available. Supercoiling that is induced by transcription has been demonstrated to have dynamic effects on DNA in the MYC promoter element: it converts duplex DNA to non-duplex DNA structures, even at considerable distances from the transcriptional start site. These non-duplex DNA structures, which control both turning on and off of transcription and the rate of transcription firing, are amenable to small-molecule targeting. This dynamic system provides a unique opportunity for the treatment of tumours in which MYC is an important oncogene.

Original languageEnglish (US)
Pages (from-to)849-861
Number of pages13
JournalNature Reviews Cancer
Volume9
Issue number12
DOIs
StatePublished - Dec 2009

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DNA
Therapeutics
Oncogenes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. / Brooks, Tracy A.; Hurley, Laurence.

In: Nature Reviews Cancer, Vol. 9, No. 12, 12.2009, p. 849-861.

Research output: Contribution to journalArticle

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