The role of the effective concentration in interpreting hemolysis data

G. H. Ward, S. H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re- examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.

Original languageEnglish (US)
Pages (from-to)161-162
Number of pages2
JournalJournal of Parenteral Science and Technology
Volume46
Issue number5
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pharmaceutical Science

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