The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

Juan J. Blondet, Annelisa M. Carlson, Takashi Kobayashi, Tun Jie, Melena Bellin, Bernhard J. Hering, Martin L. Freeman, Greg J. Beilman, David E.R. Sutherland

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Abstract

Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing insulin secretory capacity to be preserved, minimizing or preventing diabetes, while at the same time removing the root cause of the pain. Since the first case in 1977, several series have been published. Pain relief is obtained in most patients, and insulin independence preserved long term in about a third, with another third having sufficient beta cell function so that the surgical diabetes is mild. Islet autotransplantation has been done with partial or total pancreatectomy for benign and premalignant conditions. Islet autotransplantation should be used more widely to preserve beta cell mass in major pancreatic resections.

Original languageEnglish (US)
Pages (from-to)1477-1501
Number of pages25
JournalSurgical Clinics of North America
Volume87
Issue number6
DOIs
StatePublished - Dec 1 2007

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ASJC Scopus subject areas

  • Surgery

Cite this

Blondet, J. J., Carlson, A. M., Kobayashi, T., Jie, T., Bellin, M., Hering, B. J., Freeman, M. L., Beilman, G. J., & Sutherland, D. E. R. (2007). The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis. Surgical Clinics of North America, 87(6), 1477-1501. https://doi.org/10.1016/j.suc.2007.08.014