The sex hormone-dependent development of opiate receptors in the rat medial preoptic area

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The opiate receptor content of the sexually dimorphic medial preoptic area (MPOA) was examined in newborn and 5-day-old (D6) male and female rats. A significant increase of [3H]naloxone binding was observed in and around the sexually dimorphic nucleus of the preoptic area (SDN-POA) in D6 female rats, relative to newborn females. Opiate receptor labeling did not increase over this period in males, nor was labeling different between males and females at birth. This dramatic alteration of MPOA opiate receptor content was observed to occur in either sex in the absence of testosterone postnatally; that is, neonatally-castrated males exhibited the same increase of labeling by D6 as did normal females. Conversely, daily postnatal testosterone treatment of females from birth to D6 resulted in the development of male-like MPOA opiate receptor pattern. The sex hormone-dependence of MPOA opiate receptor development is discussed in relation to the sex hormone-dependent ontogeny of SDN-POA structure. The overlap of critical periods for the development of these structural and chemical sexual dimorphisms suggests a role for endogenous opioids in modulating MPOA development.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalBrain Research
Volume360
Issue number1-2
DOIs
StatePublished - Dec 23 1985
Externally publishedYes

Fingerprint

Preoptic Area
Gonadal Steroid Hormones
Opioid Receptors
Testosterone
Parturition
Naloxone
Sex Characteristics
Opioid Analgesics

Keywords

  • development
  • medial preoptic area
  • opiate receptor
  • sex hormone
  • sexual dimorphism

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The sex hormone-dependent development of opiate receptors in the rat medial preoptic area. / Hammer, Ronald P.

In: Brain Research, Vol. 360, No. 1-2, 23.12.1985, p. 65-74.

Research output: Contribution to journalArticle

@article{0d0216851ba74023a0b4284d00badb0b,
title = "The sex hormone-dependent development of opiate receptors in the rat medial preoptic area",
abstract = "The opiate receptor content of the sexually dimorphic medial preoptic area (MPOA) was examined in newborn and 5-day-old (D6) male and female rats. A significant increase of [3H]naloxone binding was observed in and around the sexually dimorphic nucleus of the preoptic area (SDN-POA) in D6 female rats, relative to newborn females. Opiate receptor labeling did not increase over this period in males, nor was labeling different between males and females at birth. This dramatic alteration of MPOA opiate receptor content was observed to occur in either sex in the absence of testosterone postnatally; that is, neonatally-castrated males exhibited the same increase of labeling by D6 as did normal females. Conversely, daily postnatal testosterone treatment of females from birth to D6 resulted in the development of male-like MPOA opiate receptor pattern. The sex hormone-dependence of MPOA opiate receptor development is discussed in relation to the sex hormone-dependent ontogeny of SDN-POA structure. The overlap of critical periods for the development of these structural and chemical sexual dimorphisms suggests a role for endogenous opioids in modulating MPOA development.",
keywords = "development, medial preoptic area, opiate receptor, sex hormone, sexual dimorphism",
author = "Hammer, {Ronald P}",
year = "1985",
month = "12",
day = "23",
doi = "10.1016/0006-8993(85)91221-1",
language = "English (US)",
volume = "360",
pages = "65--74",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - The sex hormone-dependent development of opiate receptors in the rat medial preoptic area

AU - Hammer, Ronald P

PY - 1985/12/23

Y1 - 1985/12/23

N2 - The opiate receptor content of the sexually dimorphic medial preoptic area (MPOA) was examined in newborn and 5-day-old (D6) male and female rats. A significant increase of [3H]naloxone binding was observed in and around the sexually dimorphic nucleus of the preoptic area (SDN-POA) in D6 female rats, relative to newborn females. Opiate receptor labeling did not increase over this period in males, nor was labeling different between males and females at birth. This dramatic alteration of MPOA opiate receptor content was observed to occur in either sex in the absence of testosterone postnatally; that is, neonatally-castrated males exhibited the same increase of labeling by D6 as did normal females. Conversely, daily postnatal testosterone treatment of females from birth to D6 resulted in the development of male-like MPOA opiate receptor pattern. The sex hormone-dependence of MPOA opiate receptor development is discussed in relation to the sex hormone-dependent ontogeny of SDN-POA structure. The overlap of critical periods for the development of these structural and chemical sexual dimorphisms suggests a role for endogenous opioids in modulating MPOA development.

AB - The opiate receptor content of the sexually dimorphic medial preoptic area (MPOA) was examined in newborn and 5-day-old (D6) male and female rats. A significant increase of [3H]naloxone binding was observed in and around the sexually dimorphic nucleus of the preoptic area (SDN-POA) in D6 female rats, relative to newborn females. Opiate receptor labeling did not increase over this period in males, nor was labeling different between males and females at birth. This dramatic alteration of MPOA opiate receptor content was observed to occur in either sex in the absence of testosterone postnatally; that is, neonatally-castrated males exhibited the same increase of labeling by D6 as did normal females. Conversely, daily postnatal testosterone treatment of females from birth to D6 resulted in the development of male-like MPOA opiate receptor pattern. The sex hormone-dependence of MPOA opiate receptor development is discussed in relation to the sex hormone-dependent ontogeny of SDN-POA structure. The overlap of critical periods for the development of these structural and chemical sexual dimorphisms suggests a role for endogenous opioids in modulating MPOA development.

KW - development

KW - medial preoptic area

KW - opiate receptor

KW - sex hormone

KW - sexual dimorphism

UR - http://www.scopus.com/inward/record.url?scp=0022392912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022392912&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)91221-1

DO - 10.1016/0006-8993(85)91221-1

M3 - Article

C2 - 3000537

AN - SCOPUS:0022392912

VL - 360

SP - 65

EP - 74

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -