The sexually dimorphic region of the preoptic area in rats contains denser opiate receptor binding sites in females

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Abstract

Quantitative autoradiographic analysis of opiate receptor binding using [3H]naloxone shows higher levels in the sexually dimorphic region of the medial preoptic area in female rats than in males. Opiate receptor density varies across the estrous cycle being densest in diestrous females. The sexually dimorphic nucleus of the preoptic are lies within the opiate receptor-rich region. Endogenous opiates in the medial preoptic region acting at opiate receptors which are of differential density in males and females could influence sex-specific behavior mediated by the region.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalBrain Research
Volume308
Issue number1
DOIs
StatePublished - Aug 6 1984
Externally publishedYes

Keywords

  • estrous stages
  • medial preoptic area
  • opiate receptors
  • sexual dimorphism

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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