The shunt problem: Control of functional shunting in normal and tumour vasculature

Axel R. Pries, Michael Höpfner, Ferdinand Le Noble, Mark W. Dewhirst, Timothy W Secomb

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalNature Reviews Cancer
Volume10
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Blood Vessels
Neoplasms
Microcirculation
Microvessels
Hypoxia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The shunt problem : Control of functional shunting in normal and tumour vasculature. / Pries, Axel R.; Höpfner, Michael; Le Noble, Ferdinand; Dewhirst, Mark W.; Secomb, Timothy W.

In: Nature Reviews Cancer, Vol. 10, No. 8, 08.2010, p. 587-593.

Research output: Contribution to journalArticle

Pries, Axel R. ; Höpfner, Michael ; Le Noble, Ferdinand ; Dewhirst, Mark W. ; Secomb, Timothy W. / The shunt problem : Control of functional shunting in normal and tumour vasculature. In: Nature Reviews Cancer. 2010 ; Vol. 10, No. 8. pp. 587-593.
@article{83199fc81b6a4be59bcac0c2f633bb45,
title = "The shunt problem: Control of functional shunting in normal and tumour vasculature",
abstract = "Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.",
author = "Pries, {Axel R.} and Michael H{\"o}pfner and {Le Noble}, Ferdinand and Dewhirst, {Mark W.} and Secomb, {Timothy W}",
year = "2010",
month = "8",
doi = "10.1038/nrc2895",
language = "English (US)",
volume = "10",
pages = "587--593",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - The shunt problem

T2 - Control of functional shunting in normal and tumour vasculature

AU - Pries, Axel R.

AU - Höpfner, Michael

AU - Le Noble, Ferdinand

AU - Dewhirst, Mark W.

AU - Secomb, Timothy W

PY - 2010/8

Y1 - 2010/8

N2 - Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.

AB - Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathways become enlarged and flow bypasses long pathways). Such adaptation requires information about tissue metabolic status to be communicated upstream to feeding vessels, through conducted responses. We propose that impaired vascular communication in tumour microvascular networks, leading to functional shunting, is a primary cause of dysfunctional microcirculation and local hypoxia in cancer. We suggest that anti-angiogenic treatment of tumours may restore vascular communication and thereby improve or normalize flow distribution in tumour vasculature.

UR - http://www.scopus.com/inward/record.url?scp=77954955587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954955587&partnerID=8YFLogxK

U2 - 10.1038/nrc2895

DO - 10.1038/nrc2895

M3 - Article

C2 - 20631803

AN - SCOPUS:77954955587

VL - 10

SP - 587

EP - 593

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 8

ER -