The small airways and distal lung compartment in asthma and COPD: A time for reappraisal

M. Contoli, J. Bousquet, L. M. Fabbri, H. Magnussen, K. F. Rabe, N. M. Siafakas, Q. Hamid, M. Kraft

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

The involvement of small airways in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been debated for a long time. However, a proper definition of small airway disease is still lacking, and neither a widely accepted biomarker nor a functional parameter to assess small airway abnormalities and to explore the effect of tested compounds on small airways is available. Aiming towards increased knowledge and consensus on this topic, this perspective paper intends to (i) strengthen awareness among the scientific community on the role of small airways in asthma and COPD; (ii) examine the pros and cons of some biological, functional and imaging parameters in the assessment of small airway abnormalities; and (iii) discuss the evidence for distal airway pharmacological targeting in asthma and COPD.

Original languageEnglish (US)
Pages (from-to)141-151
Number of pages11
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Keywords

  • Airway inflammation
  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Small airways
  • Treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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