The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems

Wilmarie Flores-Santana, Debra J. Salmon, Sonia Donzelli, Christopher H. Switzer, Debashree Basudhar, Lisa Ridnour, Robert Cheng, Sharon A. Glynn, Nazareno Paolocci, Jon M. Fukuto, Katrina M Miranda, David A. Wink

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.

Original languageEnglish (US)
Pages (from-to)1659-1674
Number of pages16
JournalAntioxidants and Redox Signaling
Volume14
Issue number9
DOIs
StatePublished - May 1 2011

Fingerprint

Nitrogen Oxides
Biological systems
Nitric Oxide
Biosynthesis
Physiology
Alcoholism
Oxidation-Reduction
Pharmacology
Neoplasms
nitroxyl

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Flores-Santana, W., Salmon, D. J., Donzelli, S., Switzer, C. H., Basudhar, D., Ridnour, L., ... Wink, D. A. (2011). The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants and Redox Signaling, 14(9), 1659-1674. https://doi.org/10.1089/ars.2010.3841

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. / Flores-Santana, Wilmarie; Salmon, Debra J.; Donzelli, Sonia; Switzer, Christopher H.; Basudhar, Debashree; Ridnour, Lisa; Cheng, Robert; Glynn, Sharon A.; Paolocci, Nazareno; Fukuto, Jon M.; Miranda, Katrina M; Wink, David A.

In: Antioxidants and Redox Signaling, Vol. 14, No. 9, 01.05.2011, p. 1659-1674.

Research output: Contribution to journalArticle

Flores-Santana, W, Salmon, DJ, Donzelli, S, Switzer, CH, Basudhar, D, Ridnour, L, Cheng, R, Glynn, SA, Paolocci, N, Fukuto, JM, Miranda, KM & Wink, DA 2011, 'The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems', Antioxidants and Redox Signaling, vol. 14, no. 9, pp. 1659-1674. https://doi.org/10.1089/ars.2010.3841
Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L et al. The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants and Redox Signaling. 2011 May 1;14(9):1659-1674. https://doi.org/10.1089/ars.2010.3841
Flores-Santana, Wilmarie ; Salmon, Debra J. ; Donzelli, Sonia ; Switzer, Christopher H. ; Basudhar, Debashree ; Ridnour, Lisa ; Cheng, Robert ; Glynn, Sharon A. ; Paolocci, Nazareno ; Fukuto, Jon M. ; Miranda, Katrina M ; Wink, David A. / The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. In: Antioxidants and Redox Signaling. 2011 ; Vol. 14, No. 9. pp. 1659-1674.
@article{f09aaaefed57413793762f5081e64cde,
title = "The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems",
abstract = "The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.",
author = "Wilmarie Flores-Santana and Salmon, {Debra J.} and Sonia Donzelli and Switzer, {Christopher H.} and Debashree Basudhar and Lisa Ridnour and Robert Cheng and Glynn, {Sharon A.} and Nazareno Paolocci and Fukuto, {Jon M.} and Miranda, {Katrina M} and Wink, {David A.}",
year = "2011",
month = "5",
day = "1",
doi = "10.1089/ars.2010.3841",
language = "English (US)",
volume = "14",
pages = "1659--1674",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "9",

}

TY - JOUR

T1 - The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems

AU - Flores-Santana, Wilmarie

AU - Salmon, Debra J.

AU - Donzelli, Sonia

AU - Switzer, Christopher H.

AU - Basudhar, Debashree

AU - Ridnour, Lisa

AU - Cheng, Robert

AU - Glynn, Sharon A.

AU - Paolocci, Nazareno

AU - Fukuto, Jon M.

AU - Miranda, Katrina M

AU - Wink, David A.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.

AB - The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.

UR - http://www.scopus.com/inward/record.url?scp=79953772889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953772889&partnerID=8YFLogxK

U2 - 10.1089/ars.2010.3841

DO - 10.1089/ars.2010.3841

M3 - Article

C2 - 21235346

AN - SCOPUS:79953772889

VL - 14

SP - 1659

EP - 1674

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 9

ER -