The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems

Wilmarie Flores-Santana, Debra J. Salmon, Sonia Donzelli, Christopher H. Switzer, Debashree Basudhar, Lisa Ridnour, Robert Cheng, Sharon A. Glynn, Nazareno Paolocci, Jon M. Fukuto, Katrina M. Miranda, David A. Wink

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.

Original languageEnglish (US)
Pages (from-to)1659-1674
Number of pages16
JournalAntioxidants and Redox Signaling
Volume14
Issue number9
DOIs
StatePublished - May 1 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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    Flores-Santana, W., Salmon, D. J., Donzelli, S., Switzer, C. H., Basudhar, D., Ridnour, L., Cheng, R., Glynn, S. A., Paolocci, N., Fukuto, J. M., Miranda, K. M., & Wink, D. A. (2011). The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants and Redox Signaling, 14(9), 1659-1674. https://doi.org/10.1089/ars.2010.3841