The structure of polyamine analogues determines haemoglobin production and cytotoxicity in murine erythroleukaemia cells

S. Clement, J. G. Delcros, H. S. Basu, G. Quash, L. J. Marton, B. G. Feuerstein

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. We have studied the ability of various polyamine analogues to inhibit cell growth and induce haemoglobin production. Polyamine analogues with free terminal amine groups were good inducers of haemoglobin production in MEL cells. Haemoglobin levels correlated with the number of positive charges: pentamines (five positive charges) were stronger inducers than tetramines (four positive charges). Compounds ethylated at their terminal amines were poor inducers of haemoglobin production but good inhibitors of MEL cell growth. These results provide evidence the polyamine analogues support specific biological functions of polyamines in MEL cells and suggest relationships between polyamine structure and function.

Original languageEnglish (US)
Pages (from-to)787-791
Number of pages5
JournalBiochemical Journal
Volume309
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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