The use of bioactive glass S53P4 in the treatment of an infected Charcot foot: A case report

Alexandre L. Godoy-Santos, Laercio A. Rosemberg, Cesar De Cesar-Netto, David G Armstrong

Research output: Contribution to journalArticle

Abstract

Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot. Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass. Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated. Declaration of interest: No potential conflicts of interest relevant to this article were reported.

Original languageEnglish (US)
Pages (from-to)S14-S17
JournalJournal of wound care
Volume28
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Foot
Bone and Bones
Salvage Therapy
Limb Salvage
Weight-Bearing
Glass
Negative-Pressure Wound Therapy
Therapeutics
Conflict of Interest
Diabetic Foot
Debridement
Secondary Prevention
Infection
Gait
Type 2 Diabetes Mellitus
Drainage
bioactive glass S53P4
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Fundamentals and skills
  • Nursing (miscellaneous)

Cite this

The use of bioactive glass S53P4 in the treatment of an infected Charcot foot : A case report. / Godoy-Santos, Alexandre L.; Rosemberg, Laercio A.; De Cesar-Netto, Cesar; Armstrong, David G.

In: Journal of wound care, Vol. 28, 01.01.2019, p. S14-S17.

Research output: Contribution to journalArticle

Godoy-Santos, Alexandre L. ; Rosemberg, Laercio A. ; De Cesar-Netto, Cesar ; Armstrong, David G. / The use of bioactive glass S53P4 in the treatment of an infected Charcot foot : A case report. In: Journal of wound care. 2019 ; Vol. 28. pp. S14-S17.
@article{8f37654403534110bb409c28d0b71a00,
title = "The use of bioactive glass S53P4 in the treatment of an infected Charcot foot: A case report",
abstract = "Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot. Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass. Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated. Declaration of interest: No potential conflicts of interest relevant to this article were reported.",
author = "Godoy-Santos, {Alexandre L.} and Rosemberg, {Laercio A.} and {De Cesar-Netto}, Cesar and Armstrong, {David G}",
year = "2019",
month = "1",
day = "1",
doi = "10.12968/jowc.2019.28.sup1.s14",
language = "English (US)",
volume = "28",
pages = "S14--S17",
journal = "Journal of wound care",
issn = "0969-0700",
publisher = "MA Healthcare Ltd",

}

TY - JOUR

T1 - The use of bioactive glass S53P4 in the treatment of an infected Charcot foot

T2 - A case report

AU - Godoy-Santos, Alexandre L.

AU - Rosemberg, Laercio A.

AU - De Cesar-Netto, Cesar

AU - Armstrong, David G

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot. Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass. Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated. Declaration of interest: No potential conflicts of interest relevant to this article were reported.

AB - Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot. Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass. Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated. Declaration of interest: No potential conflicts of interest relevant to this article were reported.

UR - http://www.scopus.com/inward/record.url?scp=85061137238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061137238&partnerID=8YFLogxK

U2 - 10.12968/jowc.2019.28.sup1.s14

DO - 10.12968/jowc.2019.28.sup1.s14

M3 - Article

C2 - 30724119

AN - SCOPUS:85061137238

VL - 28

SP - S14-S17

JO - Journal of wound care

JF - Journal of wound care

SN - 0969-0700

ER -