The use of two measures of health-related quality of life in HIV-infected individuals: A cross-sectional comparison

A. E. Copfer, N. M. Ampel, T. E. Hughes, K. J. Gregor, C. L. Dols, S. J. Coons, K. Colgan, A. W. Wu

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Two measures of health-related quality of life in 65 HIV-infected individuals were compared in a cross-sectional design. The Quality of WeIl-Being Scale (QWB) results in a single score ranging from death to perfect hearth. The MOS-HIV Hearth Survey (MOS-HIV, 34 item version) gives scores in 11 dimensions. The QWB score distinguished subjects with AIDS from those who were asymptomatic (p = 0.027). For the seven multi-item scares of the MOS-HIV, Cronbach's alpha ranged from 0.85-0.95, indicating good internal consistency reliability. Clinical HIV-infection status was significantly associated with the dimensions of Overall Health (p = 0.002), Role Function (p = 0.022), Social Function (p = 0.037), Energy/Fatigue (p = 0.027) and Health Distress (p = 0.025). All eleven dimensions of the MOS-HIV were significantly correlated with the QWB score (Spearman's coefficient = 0.405-0.670; for all, p < 0.01) and the QWB score could be predicted from the MOS-HIV dimension scores using multiple regression. The QWB and the MOS-HIV may be useful in assessing health-related quality of life in patients infected with HIV.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalQuality of Life Research
Issue number2
StatePublished - Jun 10 1996



  • Acquired immunodeficiency Syndrome
  • HIV-infection
  • Health status
  • Quality of life
  • Questionnaires

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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