The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalPhysiology
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

Perimenopause
Menopause
Sex Characteristics
Cardiovascular Diseases
Diabetic Nephropathies
Ovarian Neoplasms
Osteoporosis
Ovary
Rodentia
Hypertension

ASJC Scopus subject areas

  • Physiology

Cite this

The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome. / Brooks, Heddwen L; Pollow, D. P.; Hoyer, Patricia B.

In: Physiology, Vol. 31, No. 4, 01.07.2016, p. 250-257.

Research output: Contribution to journalReview article

@article{2a07924e6b6e4c7397c6ee556b7120f0,
title = "The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome",
abstract = "In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.",
author = "Brooks, {Heddwen L} and Pollow, {D. P.} and Hoyer, {Patricia B}",
year = "2016",
month = "7",
day = "1",
doi = "10.1152/physiol.00057.2014",
language = "English (US)",
volume = "31",
pages = "250--257",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome

AU - Brooks, Heddwen L

AU - Pollow, D. P.

AU - Hoyer, Patricia B

PY - 2016/7/1

Y1 - 2016/7/1

N2 - In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.

AB - In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.

UR - http://www.scopus.com/inward/record.url?scp=84983792620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983792620&partnerID=8YFLogxK

U2 - 10.1152/physiol.00057.2014

DO - 10.1152/physiol.00057.2014

M3 - Review article

C2 - 27252160

AN - SCOPUS:84983792620

VL - 31

SP - 250

EP - 257

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 4

ER -