The Yin and Yang of VEGF and PEDF

Multifaceted neurotrophic factors and their potential in the treatment of Parkinson's disease

Torsten Falk, Robert T. Gonzalez, Scott J Sherman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)2875-2900
Number of pages26
JournalInternational Journal of Molecular Sciences
Volume11
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Yin-Yang
Parkinson disease
epithelium
Nerve Growth Factors
pigments
Pigments
Vascular Endothelial Growth Factor A
Parkinson Disease
Cardiology
Neuroprotective Agents
Crosstalk
Neurodegenerative Diseases
Intercellular Signaling Peptides and Proteins
cardiology
pathogenesis
Therapeutics
crosstalk
biology
Neoplasms
cascades

Keywords

  • Neurodegeneration
  • PEDF
  • PEDF-R
  • VEGF-A
  • VEGF-B
  • VEGFR1
  • VEGFR2

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

@article{aca24c2caf7e41a8b9d91dbfa1681e3d,
title = "The Yin and Yang of VEGF and PEDF: Multifaceted neurotrophic factors and their potential in the treatment of Parkinson's disease",
abstract = "Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson's disease.",
keywords = "Neurodegeneration, PEDF, PEDF-R, VEGF-A, VEGF-B, VEGFR1, VEGFR2",
author = "Torsten Falk and Gonzalez, {Robert T.} and Sherman, {Scott J}",
year = "2010",
month = "8",
doi = "10.3390/ijms11082875",
language = "English (US)",
volume = "11",
pages = "2875--2900",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - The Yin and Yang of VEGF and PEDF

T2 - Multifaceted neurotrophic factors and their potential in the treatment of Parkinson's disease

AU - Falk, Torsten

AU - Gonzalez, Robert T.

AU - Sherman, Scott J

PY - 2010/8

Y1 - 2010/8

N2 - Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson's disease.

AB - Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson's disease.

KW - Neurodegeneration

KW - PEDF

KW - PEDF-R

KW - VEGF-A

KW - VEGF-B

KW - VEGFR1

KW - VEGFR2

UR - http://www.scopus.com/inward/record.url?scp=77957928091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957928091&partnerID=8YFLogxK

U2 - 10.3390/ijms11082875

DO - 10.3390/ijms11082875

M3 - Article

VL - 11

SP - 2875

EP - 2900

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 8

ER -