The Yin and Yang of VEGF and PEDF: Multifaceted neurotrophic factors and their potential in the treatment of Parkinson's disease

Torsten Falk, Robert T. Gonzalez, Scott J. Sherman

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)2875-2900
Number of pages26
JournalInternational journal of molecular sciences
Volume11
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Neurodegeneration
  • PEDF
  • PEDF-R
  • VEGF-A
  • VEGF-B
  • VEGFR1
  • VEGFR2

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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