Theoretical study of structural adaptation in microvascular networks: effect of metabolic response on distribution of blood flow between long and short pathways

Gabriel Gruionu, Timothy W Secomb, Axel R. Pries

Research output: Contribution to journalArticle


The goal of the present study was to investigate how the process of vascular adaptation can ensure that the flow is well distributed among flow pathways through the network, even though the pressure gradient is higher in shorter pathways. A previously developed theoretical model was used to simulate the effect of the metabolic response on flow distribution in a simple hypothetical network with two long flow pathways and one shorter pathway between the inflow and the outflow. The metabolic response represents the tendency of a slowly flowing, poorly oxygenated segment to increase its diameter.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
Publication statusPublished - 2000


ASJC Scopus subject areas

  • Biomedical Engineering

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