Therapeutic applications of lipid-coated microbubbles

Evan C. Unger, Thomas Porter, William Culp, Rachel Labell, Terry Matsunaga, Reena Zutshi

Research output: Contribution to journalArticlepeer-review

461 Scopus citations

Abstract

Lipid-coated microbubbles represent a new class of agents with both diagnostic and therapeutic applications. Microbubbles have low density. Stabilization of microbubbles by lipid coatings creates low-density particles with unusual properties for diagnostic imaging and drug delivery. Perfluorocarbon (PFC) gases entrapped within lipid coatings make microbubbles that are sufficiently stable for circulation in the vasculature as blood pool agents. Microbubbles can be cavitated with ultrasound energy for site-specific local delivery of bioactive materials and for treatment of vascular thrombosis. The blood-brain barrier (BBB) can be reversibly opened without damaging the neurons using ultrasound applied across the intact skull to cavitate microbubbles within the cerebral microvasculature for delivery of both low and high molecular weight therapeutic compounds to the brain. The first lipid-coated PFC microbubble product is currently marketed for diagnostic ultrasound imaging. Clinical trials are currently in process for treatment of vascular thrombosis with ultrasound and lipid-coated PFC microbubbles (SonoLysis™ Therapy). Targeted microbubbles and acoustically active PFC nanoemulsions with specific ligands can be developed for detecting disease at the molecular level and targeted drug and gene delivery. Bioactive compounds can be incorporated into these carriers for site-specific delivery. Our aim is to cover the therapeutic applications of lipid-coated microbubbles and PFC emulsions in this review.

Original languageEnglish (US)
Pages (from-to)1291-1314
Number of pages24
JournalAdvanced Drug Delivery Reviews
Volume56
Issue number9
DOIs
StatePublished - May 7 2004

Keywords

  • Blood-brain barrier
  • Cavitation
  • Clot lysis
  • Drug delivery
  • Emulsions
  • Gene delivery
  • Lipid
  • Microbubbles
  • Microspheres
  • Perfluorocarbon
  • Sonothrombolysis
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science

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