Therapeutic applications of microbubbles

Evan C Unger, Terry O Matsunaga, Thomas McCreery, Patricia Schumann, Robert Sweitzer, Rachel Quigley

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.

Original languageEnglish (US)
Pages (from-to)160-168
Number of pages9
JournalEuropean Journal of Radiology
Volume42
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Microbubbles
Therapeutics
Drug Delivery Systems
Pharmaceutical Preparations
Contrast Media
Thrombosis
Ligands
Genes

Keywords

  • Drug delivery
  • Gene delivery
  • Microbubbles
  • Therapy
  • Thrombolysis
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Therapeutic applications of microbubbles. / Unger, Evan C; Matsunaga, Terry O; McCreery, Thomas; Schumann, Patricia; Sweitzer, Robert; Quigley, Rachel.

In: European Journal of Radiology, Vol. 42, No. 2, 2002, p. 160-168.

Research output: Contribution to journalArticle

Unger, EC, Matsunaga, TO, McCreery, T, Schumann, P, Sweitzer, R & Quigley, R 2002, 'Therapeutic applications of microbubbles', European Journal of Radiology, vol. 42, no. 2, pp. 160-168. https://doi.org/10.1016/S0720-048X(01)00455-7
Unger, Evan C ; Matsunaga, Terry O ; McCreery, Thomas ; Schumann, Patricia ; Sweitzer, Robert ; Quigley, Rachel. / Therapeutic applications of microbubbles. In: European Journal of Radiology. 2002 ; Vol. 42, No. 2. pp. 160-168.
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