Therapeutic applications of microbubbles

Evan C. Unger, Terry Onichi Matsunaga, Thomas McCreery, Patricia Schumann, Robert Sweitzer, Rachel Quigley

Research output: Contribution to journalArticlepeer-review

244 Scopus citations

Abstract

Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.

Original languageEnglish (US)
Pages (from-to)160-168
Number of pages9
JournalEuropean Journal of Radiology
Volume42
Issue number2
DOIs
StatePublished - Apr 23 2002
Externally publishedYes

Keywords

  • Drug delivery
  • Gene delivery
  • Microbubbles
  • Therapy
  • Thrombolysis
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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