Therapy of symptomatic pericarditis after myocardial infarction: Retrospective and prospective studies of aspirin, indomethacin, prednisone, and spontaneous resolution

Jay Berman, Charles I. Haffajee, Joseph S Alpert

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We studied the efficacy of aspirin and indomethacin therapy in relieving the discomfort of postmyocardial infarction pericarditis (PMIP) in two studies: (1) a retrospective evaluation of patients with symptomatic PMIP during a 5-year period and (2) a prospective, randomized, single-blind comparison of aspirin and indomethacin in similar patients. In the retrospective study, 36 episodes of symptomatic PMIP in 34 patients were identified; in the prospective study, 25 episodes of PMIP in 24 patients occurred. Relief from the discomfort of PMIP was noted within 48 hours in almost all patients with either indomethacin or aspirin therapy. Minor gastrointestinal bleeding developed in two patients in the retrospective study and in two patients in the prospective study. In the retrospective study, mild discomfort of PMIP abated within 48 hours in five of eight patients who received either no treatment or minor analgesic therapy. Aspirin and indomethacin are equally efficacious in relieving the discomfort of PMIP.

Original languageEnglish (US)
Pages (from-to)750-753
Number of pages4
JournalAmerican Heart Journal
Volume101
Issue number6
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Pericarditis
Prednisone
Indomethacin
Aspirin
Infarction
Retrospective Studies
Myocardial Infarction
Prospective Studies
Therapeutics
Analgesics
Hemorrhage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{b477c8be816042008de7b49316669156,
title = "Therapy of symptomatic pericarditis after myocardial infarction: Retrospective and prospective studies of aspirin, indomethacin, prednisone, and spontaneous resolution",
abstract = "We studied the efficacy of aspirin and indomethacin therapy in relieving the discomfort of postmyocardial infarction pericarditis (PMIP) in two studies: (1) a retrospective evaluation of patients with symptomatic PMIP during a 5-year period and (2) a prospective, randomized, single-blind comparison of aspirin and indomethacin in similar patients. In the retrospective study, 36 episodes of symptomatic PMIP in 34 patients were identified; in the prospective study, 25 episodes of PMIP in 24 patients occurred. Relief from the discomfort of PMIP was noted within 48 hours in almost all patients with either indomethacin or aspirin therapy. Minor gastrointestinal bleeding developed in two patients in the retrospective study and in two patients in the prospective study. In the retrospective study, mild discomfort of PMIP abated within 48 hours in five of eight patients who received either no treatment or minor analgesic therapy. Aspirin and indomethacin are equally efficacious in relieving the discomfort of PMIP.",
author = "Jay Berman and Haffajee, {Charles I.} and Alpert, {Joseph S}",
year = "1981",
doi = "10.1016/0002-8703(81)90610-4",
language = "English (US)",
volume = "101",
pages = "750--753",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Therapy of symptomatic pericarditis after myocardial infarction

T2 - Retrospective and prospective studies of aspirin, indomethacin, prednisone, and spontaneous resolution

AU - Berman, Jay

AU - Haffajee, Charles I.

AU - Alpert, Joseph S

PY - 1981

Y1 - 1981

N2 - We studied the efficacy of aspirin and indomethacin therapy in relieving the discomfort of postmyocardial infarction pericarditis (PMIP) in two studies: (1) a retrospective evaluation of patients with symptomatic PMIP during a 5-year period and (2) a prospective, randomized, single-blind comparison of aspirin and indomethacin in similar patients. In the retrospective study, 36 episodes of symptomatic PMIP in 34 patients were identified; in the prospective study, 25 episodes of PMIP in 24 patients occurred. Relief from the discomfort of PMIP was noted within 48 hours in almost all patients with either indomethacin or aspirin therapy. Minor gastrointestinal bleeding developed in two patients in the retrospective study and in two patients in the prospective study. In the retrospective study, mild discomfort of PMIP abated within 48 hours in five of eight patients who received either no treatment or minor analgesic therapy. Aspirin and indomethacin are equally efficacious in relieving the discomfort of PMIP.

AB - We studied the efficacy of aspirin and indomethacin therapy in relieving the discomfort of postmyocardial infarction pericarditis (PMIP) in two studies: (1) a retrospective evaluation of patients with symptomatic PMIP during a 5-year period and (2) a prospective, randomized, single-blind comparison of aspirin and indomethacin in similar patients. In the retrospective study, 36 episodes of symptomatic PMIP in 34 patients were identified; in the prospective study, 25 episodes of PMIP in 24 patients occurred. Relief from the discomfort of PMIP was noted within 48 hours in almost all patients with either indomethacin or aspirin therapy. Minor gastrointestinal bleeding developed in two patients in the retrospective study and in two patients in the prospective study. In the retrospective study, mild discomfort of PMIP abated within 48 hours in five of eight patients who received either no treatment or minor analgesic therapy. Aspirin and indomethacin are equally efficacious in relieving the discomfort of PMIP.

UR - http://www.scopus.com/inward/record.url?scp=0019472512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019472512&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(81)90610-4

DO - 10.1016/0002-8703(81)90610-4

M3 - Article

C2 - 7234652

AN - SCOPUS:0019472512

VL - 101

SP - 750

EP - 753

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 6

ER -