Therapy operating characteristic curves: Tools for precision chemotherapy

Harrison H Barrett, David S Alberts, James M. Woolfenden, Luca Caucci, John W. Hoppin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The therapy operating characteristic (TOC) curve, developed in the context of radiation therapy, is a plot of the probability of tumor control versus the probability of normal-tissue complications as the overall radiation dose level is varied, e.g., by varying the beam current in external-beam radiotherapy or the total injected activity in radionuclide therapy. This paper shows how TOC can be applied to chemotherapy with the administered drug dosage as the variable. The area under a TOC curve (AUTOC) can be used as a figure of merit for therapeutic efficacy, analogous to the area under an ROC curve (AUROC), which is a figure of merit for diagnostic efficacy. In radiation therapy, AUTOC can be computed for a single patient by using image data along with radiobiological models for tumor response and adverse side effects. The mathematical analogy between response of observers to images and the response of tumors to distributions of a chemotherapy drug is exploited to obtain linear discriminant functions from which AUTOC can be calculated. Methods for using mathematical models of drug delivery and tumor response with imaging data to estimate patient-specific parameters that are needed for calculation of AUTOC are outlined. The implications of this viewpoint for clinical trials are discussed.

Original languageEnglish (US)
Article number023502
JournalJournal of Medical Imaging
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Chemotherapy
Tumors
Radiotherapy
Drug Therapy
Drug dosage
Neoplasms
Pharmaceutical Preparations
Therapeutics
Drug delivery
Radioisotopes
Dosimetry
ROC Curve
Area Under Curve
Tissue
Mathematical models
Imaging techniques
Theoretical Models
Clinical Trials
Radiation

Keywords

  • chemotherapy
  • normal tissue complications
  • positron emission tomography
  • radiation therapy
  • single-photon emission computed tomography
  • Therapy operating characteristic
  • tumor control

ASJC Scopus subject areas

  • Bioengineering
  • Radiology Nuclear Medicine and imaging

Cite this

Therapy operating characteristic curves : Tools for precision chemotherapy. / Barrett, Harrison H; Alberts, David S; Woolfenden, James M.; Caucci, Luca; Hoppin, John W.

In: Journal of Medical Imaging, Vol. 3, No. 2, 023502, 01.04.2016.

Research output: Contribution to journalArticle

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