Thermography for in-vivo wound healing models

Ersilia Anghel, Manish Bharara, David G. Armstrong, Ronald L. Heimark, Gurtej Singh Grewal, Oostur Raza

Research output: Contribution to journalConference article

Abstract

The objective of this study was to create a wound healing model based on longitudinal thermal images of wounds to assess the pro-angiogenic properties of Eu(OH)3 nanorods using an in vivo animal model. Eu(OH)3 nanorods are bioactive nanoparticles and induce angiogenesis which results in relatively faster skin wound healing in diabetics. We tracked wound area of full thickness cutaneous wounds for 18 days using digital photographs and wound temperature using infrared imaging as a surrogate indictor for inflammation. Cutaneous wound area decreased faster for mice treated with Eu(OH) 3 than those treated with control vehicle dressing [62% (Europium) Vs 43% (Control) wound area reduction at Day 18]. This study provides a novel methodology to assess wound healing for in-vivo models using thermography.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalSimulation Series
Volume46
Issue number10
StatePublished - Jan 1 2014
EventSummer Computer Simulation Conference, SCSC 2014, Part of the 2014 Summer Simulation Multiconference, SummerSim 2014 - Monterey, United States
Duration: Jul 6 2014Jul 10 2014

Keywords

  • Angiogenesis
  • Diabetic Wound Healing
  • Inflammation
  • Nano-technology
  • Thermography

ASJC Scopus subject areas

  • Computer Networks and Communications

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