Thermoregulatory responses of the unrestrained cat to acute and chronic intravenous administration of low doses of morphine and to naloxone precipitated withdrawal

Edward D French, Sergio A. Vasquez, Robert George

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Morphine in doses of 1, 2, and 4 mg/kg i.v. produced dose related elevations in cat body temperature while doses of 0.25 and 0.50 mg/kg had no such effect. Tolerance was found to develop to the hyperthermic response after seven days of daily morphine injection. Pretreatment with naloxone at a dose one-fourth the dose of morphine prevented the morphine induced rise in body temperature in all cats tested. When the cats received naloxone after twelve days of daily morphine a withdrawal syndrome resulted and was accompanied by a hypothermia that was proportional to the morphine maintenance dose and severity of withdrawal.

Original languageEnglish (US)
Pages (from-to)1947-1954
Number of pages8
JournalLife Sciences
Volume22
Issue number21
DOIs
StatePublished - Jun 5 1978
Externally publishedYes

Fingerprint

Naloxone
Intravenous Administration
Morphine
Cats
Body Temperature
Hypothermia
Temperature
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Thermoregulatory responses of the unrestrained cat to acute and chronic intravenous administration of low doses of morphine and to naloxone precipitated withdrawal. / French, Edward D; Vasquez, Sergio A.; George, Robert.

In: Life Sciences, Vol. 22, No. 21, 05.06.1978, p. 1947-1954.

Research output: Contribution to journalArticle

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