Theta-band functional connectivity and single-trial cognitive control in sports-related concussion: Demonstration of proof-of-concept for a potential biomarker of concussion

Ezra E. Smith, John JB Allen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion. Methods: Participants included college-age contact/collision athletes with (N=24) and without a history of concussion (N=16) in Study 1. Study 2 (N=10) examined changes over time in contact/collision athletes. There were two primary dependent variables: (1) theta-band phase-synchronization (e.g., functional connectivity) between medial and right-lateral electrodes; and (2) the within-subject correlation between synchronization strength on error trials and post-error reaction time (i.e., operationalization of cognitive control). Results: Head injury history was inversely related with medial-lateral connectivity. Head injury was also related to declines in a neurobehavioral measure of cognitive control (i.e., the single-trial relationship between connectivity and post-error slowing). Conclusions: Results align with a theory of connectivity-mediated cognitive control. Mild injuries undetectable by behavioral measures may still be apparent on direct measures of neural functioning. This report demonstrates that connectivity and cognitive control measures may be useful for tracking recovery from concussion. Theoretically relevant neuroscientific findings in healthy adults may have applications in patient populations, especially with regard to monitoring brain health.

Original languageEnglish (US)
Pages (from-to)314-323
Number of pages10
JournalJournal of the International Neuropsychological Society
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Athletes
Sports
Biomarkers
Craniocerebral Trauma
Health
Brain
Electrodes
Wounds and Injuries
Population

Keywords

  • Athletes
  • Biomarkers
  • Cognitive function
  • EEG
  • Head injuries
  • Humans

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{fe4476ab90964e32905453791dd97cea,
title = "Theta-band functional connectivity and single-trial cognitive control in sports-related concussion: Demonstration of proof-of-concept for a potential biomarker of concussion",
abstract = "Objectives: This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion. Methods: Participants included college-age contact/collision athletes with (N=24) and without a history of concussion (N=16) in Study 1. Study 2 (N=10) examined changes over time in contact/collision athletes. There were two primary dependent variables: (1) theta-band phase-synchronization (e.g., functional connectivity) between medial and right-lateral electrodes; and (2) the within-subject correlation between synchronization strength on error trials and post-error reaction time (i.e., operationalization of cognitive control). Results: Head injury history was inversely related with medial-lateral connectivity. Head injury was also related to declines in a neurobehavioral measure of cognitive control (i.e., the single-trial relationship between connectivity and post-error slowing). Conclusions: Results align with a theory of connectivity-mediated cognitive control. Mild injuries undetectable by behavioral measures may still be apparent on direct measures of neural functioning. This report demonstrates that connectivity and cognitive control measures may be useful for tracking recovery from concussion. Theoretically relevant neuroscientific findings in healthy adults may have applications in patient populations, especially with regard to monitoring brain health.",
keywords = "Athletes, Biomarkers, Cognitive function, EEG, Head injuries, Humans",
author = "Smith, {Ezra E.} and Allen, {John JB}",
year = "2019",
month = "3",
day = "1",
doi = "10.1017/S135561771800108X",
language = "English (US)",
volume = "25",
pages = "314--323",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "3",

}

TY - JOUR

T1 - Theta-band functional connectivity and single-trial cognitive control in sports-related concussion

T2 - Demonstration of proof-of-concept for a potential biomarker of concussion

AU - Smith, Ezra E.

AU - Allen, John JB

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objectives: This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion. Methods: Participants included college-age contact/collision athletes with (N=24) and without a history of concussion (N=16) in Study 1. Study 2 (N=10) examined changes over time in contact/collision athletes. There were two primary dependent variables: (1) theta-band phase-synchronization (e.g., functional connectivity) between medial and right-lateral electrodes; and (2) the within-subject correlation between synchronization strength on error trials and post-error reaction time (i.e., operationalization of cognitive control). Results: Head injury history was inversely related with medial-lateral connectivity. Head injury was also related to declines in a neurobehavioral measure of cognitive control (i.e., the single-trial relationship between connectivity and post-error slowing). Conclusions: Results align with a theory of connectivity-mediated cognitive control. Mild injuries undetectable by behavioral measures may still be apparent on direct measures of neural functioning. This report demonstrates that connectivity and cognitive control measures may be useful for tracking recovery from concussion. Theoretically relevant neuroscientific findings in healthy adults may have applications in patient populations, especially with regard to monitoring brain health.

AB - Objectives: This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion. Methods: Participants included college-age contact/collision athletes with (N=24) and without a history of concussion (N=16) in Study 1. Study 2 (N=10) examined changes over time in contact/collision athletes. There were two primary dependent variables: (1) theta-band phase-synchronization (e.g., functional connectivity) between medial and right-lateral electrodes; and (2) the within-subject correlation between synchronization strength on error trials and post-error reaction time (i.e., operationalization of cognitive control). Results: Head injury history was inversely related with medial-lateral connectivity. Head injury was also related to declines in a neurobehavioral measure of cognitive control (i.e., the single-trial relationship between connectivity and post-error slowing). Conclusions: Results align with a theory of connectivity-mediated cognitive control. Mild injuries undetectable by behavioral measures may still be apparent on direct measures of neural functioning. This report demonstrates that connectivity and cognitive control measures may be useful for tracking recovery from concussion. Theoretically relevant neuroscientific findings in healthy adults may have applications in patient populations, especially with regard to monitoring brain health.

KW - Athletes

KW - Biomarkers

KW - Cognitive function

KW - EEG

KW - Head injuries

KW - Humans

UR - http://www.scopus.com/inward/record.url?scp=85060577930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060577930&partnerID=8YFLogxK

U2 - 10.1017/S135561771800108X

DO - 10.1017/S135561771800108X

M3 - Article

C2 - 30681045

AN - SCOPUS:85060577930

VL - 25

SP - 314

EP - 323

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 3

ER -