Thiazide-induced severe hypercalcemia: A case report and review of literature

Harit V. Desai, Kaushang Gandhi, Mala Sharma, Michaud Jennine, Parminder - Singh, Maureen Brogan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Most common causes of hypercalcemia are hyperparathyroidism, malignancy, vitamin D-mediated conditions such as sarcoidosis, and vitamin D toxicity. Less commonly, hypercalcemia can be caused by drugs such as thiazide diuretics and lithium. Mild hypercalcemia is usually asymptomatic but severe hypercalcemia is associated with nausea, vomiting, abdominal pain, excessive thirst, muscle weakness, lethargy, confusion, and fatigue. We are reporting a case of abdominal pain and altered mental status caused by thiazide-induced severe hypercalcemia of 19.8 mg/dL. This is the most severe case of thiazide-induced hypercalcemia that we have seen reported. Patients on thiazide diuretics should have their electrolytes frequently checked, especially patients on calcium supplements. Management usually includes hydration and discontinuation of drugs causing hypercalcemia.

Original languageEnglish (US)
JournalAmerican Journal of Therapeutics
Volume17
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Thiazides
Hypercalcemia
Sodium Chloride Symporter Inhibitors
Vitamin D
Abdominal Pain
Thirst
Confusion
Lethargy
Hyperparathyroidism
Muscle Weakness
Sarcoidosis
Lithium
Pharmaceutical Preparations
Nausea
Electrolytes
Vomiting
Fatigue
Calcium

Keywords

  • diuretics
  • hydrochlorothiazide
  • hypercalcemia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Thiazide-induced severe hypercalcemia : A case report and review of literature. / Desai, Harit V.; Gandhi, Kaushang; Sharma, Mala; Jennine, Michaud; Singh, Parminder -; Brogan, Maureen.

In: American Journal of Therapeutics, Vol. 17, No. 6, 11.2010.

Research output: Contribution to journalArticle

Desai, Harit V. ; Gandhi, Kaushang ; Sharma, Mala ; Jennine, Michaud ; Singh, Parminder - ; Brogan, Maureen. / Thiazide-induced severe hypercalcemia : A case report and review of literature. In: American Journal of Therapeutics. 2010 ; Vol. 17, No. 6.
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