Thielavialides A-E, nor -spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, An endophytic fungus isolated from aeroponically grown Physalis alkekengi

E. M.Kithsiri Wijeratne, Patricia Espinosa-Artiles, Raphael Gruener, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Four new nor-spiro-azaphilones, thielavialides A-D (1- 4), a new bis-spiro-azaphilone, thielavialide E (5), together with pestafolide A (6), were isolated from the endophytic fungal strain, Thielavia sp. PA0001, occurring in the healthy leaf tissue of aeroponically grown Physalis alkekengi. The structures and relative configurations of 1-5 were established on the basis of their MS and NMR data. Possible biosynthetic pathways to thielavialides A-E (1- 5) from pestafolide A (6), some involving a Favorskii-like rearrangement, are proposed.

Original languageEnglish (US)
Pages (from-to)1467-1472
Number of pages6
JournalJournal Of Natural Products
Volume77
Issue number6
DOIs
StatePublished - Jun 27 2014

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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