Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

Jiahui Zheng, Xiaoqian Liu, Qing Yuan, Yoon Joo Shin, Daekyu Sun, Yixin Lu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number6
DOIs
StatePublished - 2010

Fingerprint

DNA Cleavage
Sulfhydryl Compounds
thiols
reagents
cleavage
deoxyribonucleic acid
DNA
Sulfur
dioxides
therapy
sulfur
cancer
Neoplasms
Molecules
molecules
Therapeutics
1,2-benzodithiol-3-one-1,1-dioxide

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. / Zheng, Jiahui; Liu, Xiaoqian; Yuan, Qing; Shin, Yoon Joo; Sun, Daekyu; Lu, Yixin.

In: Organic and Biomolecular Chemistry, Vol. 8, No. 6, 2010, p. 1293-1295.

Research output: Contribution to journalArticle

Zheng, Jiahui ; Liu, Xiaoqian ; Yuan, Qing ; Shin, Yoon Joo ; Sun, Daekyu ; Lu, Yixin. / Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. In: Organic and Biomolecular Chemistry. 2010 ; Vol. 8, No. 6. pp. 1293-1295.
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