Abstract
Purpose: Current laser treatment for vascular disorders such as port wine stains can have incomplete or unacceptable results. A customized treatment strategy based on knowledge of the patient's blood vessel structure may effect an improved clinical outcome. Procedure: We tested the feasibility of using color Doppler optical coherence tomography (OCT) and image processing techniques to locate, measure and reconstruct cutaneous blood vessels in rat and hamster skin, OCT is a recent, potentially noninvasive technique for imaging subsurface tissue structures with micrometer scale resolution. Results: Blood vessels were identified in a series of cross-sectional images, then a three-dimensional reconstruction was made. Parameters that can affect optimum laser treatment parameters, such as average blood vessel depth and luminal diameter, were found from the images. Conclusion: This study shows that color Doppler OCT is a potential tool for improving laser treatment of vascular disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | Dermatology |
| Volume | 198 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1999 |
Fingerprint
Keywords
- Doppler flow
- Image analysis
- Laser therapy
- Port wine stains
ASJC Scopus subject areas
- Dermatology
Cite this
Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images. / Barton, Jennifer K; Izatt, J. A.; Kulkarni, M. D.; Yazdanfar, S.; Welch, A. J.
In: Dermatology, Vol. 198, No. 4, 1999, p. 355-361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images
AU - Barton, Jennifer K
AU - Izatt, J. A.
AU - Kulkarni, M. D.
AU - Yazdanfar, S.
AU - Welch, A. J.
PY - 1999
Y1 - 1999
N2 - Purpose: Current laser treatment for vascular disorders such as port wine stains can have incomplete or unacceptable results. A customized treatment strategy based on knowledge of the patient's blood vessel structure may effect an improved clinical outcome. Procedure: We tested the feasibility of using color Doppler optical coherence tomography (OCT) and image processing techniques to locate, measure and reconstruct cutaneous blood vessels in rat and hamster skin, OCT is a recent, potentially noninvasive technique for imaging subsurface tissue structures with micrometer scale resolution. Results: Blood vessels were identified in a series of cross-sectional images, then a three-dimensional reconstruction was made. Parameters that can affect optimum laser treatment parameters, such as average blood vessel depth and luminal diameter, were found from the images. Conclusion: This study shows that color Doppler OCT is a potential tool for improving laser treatment of vascular disorders.
AB - Purpose: Current laser treatment for vascular disorders such as port wine stains can have incomplete or unacceptable results. A customized treatment strategy based on knowledge of the patient's blood vessel structure may effect an improved clinical outcome. Procedure: We tested the feasibility of using color Doppler optical coherence tomography (OCT) and image processing techniques to locate, measure and reconstruct cutaneous blood vessels in rat and hamster skin, OCT is a recent, potentially noninvasive technique for imaging subsurface tissue structures with micrometer scale resolution. Results: Blood vessels were identified in a series of cross-sectional images, then a three-dimensional reconstruction was made. Parameters that can affect optimum laser treatment parameters, such as average blood vessel depth and luminal diameter, were found from the images. Conclusion: This study shows that color Doppler OCT is a potential tool for improving laser treatment of vascular disorders.
KW - Doppler flow
KW - Image analysis
KW - Laser therapy
KW - Port wine stains
UR - http://www.scopus.com/inward/record.url?scp=0009363792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0009363792&partnerID=8YFLogxK
U2 - 10.1159/000018148
DO - 10.1159/000018148
M3 - Article
C2 - 10449934
AN - SCOPUS:0009363792
VL - 198
SP - 355
EP - 361
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 4
ER -