Thromboelastogram evaluation of the impact of hypercoagulability in trauma patients

Bernardino C. Branco, Kenji Inaba, Crystal Ives, Obi Okoye, Ira Shulman, Jean Stephane David, Herbert Schöchl, Peter Rhee, Demetrios Demetriades

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Introduction: Admission hypocoagulability has been associated with negative outcomes after trauma. The purpose of this study was to determine the impact of hypercoagulability after trauma on the need for blood product transfusion and mortality. Methods: Injured patients meeting our level I trauma center's highest activation criteria had a thromboelastography (TEG) performed at admission, +1 h, +2 h, and +6 h using citrated blood. Hypercoagulability was defined as any TEG parameter in the hypercoagulable range, and hypocoagulability as any parameter in the hypocoagulable range. Patients were followed up prospectively throughout their hospital course. Results: A total of 118 patients were enrolled: 26.3% (n = 31) were hypercoagulable, 55.9% (n = 66) had a normal TEG profile, and 17.8% (n = 21) were hypocoagulable. After adjusting for differences in demographics and clinical data, hypercoagulable patients were less likely to require un-cross-matched blood (11.1% for hypercoagulable vs. 20.4% for normal vs. 45.7% for hypocoagulable, adjusted P = 0.004). Hypercoagulable patients required less total blood products, in particular, plasma at 6 h (0.1 [SD, 0.4] U for hypercoagulable vs. 0.7 [SD, 1.9] U for normal vs. 4.3 [SD, 6.3] U for hypocoagulable, adjusted P < 0.001) and 24 h (0.2 [SD, 0.6] U for hypercoagulable vs. 1.1 [SD, 2.9] U for normal vs. 8.2 [SD, 19.3] U for hypocoagulable, adjusted P < 0.001). Hypercoagulable patients had lower 24-h mortality (0.0% vs. 5.5% vs. 27.8%, adjusted P < 0.001) and 7-day mortality (0.0% vs. 5.5% vs. 36.1%, adjusted P < 0.001). Bleeding-related deaths were less likely in the hypercoagulable group (0.0% vs. 1.8% vs. 25.0%, adjusted P < 0.001). Conclusions: Approximately a quarter of trauma patients presented in a hypercoagulable state. Hypercoagulable patients required less blood products, in particular plasma. They also had a lower 24-h and 7-day mortality and lower rates of bleeding-related deaths. Further evaluation of the mechanism responsible for the hypercoagulable state and its implications on outcome is warranted.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalShock
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2014

Keywords

  • Hypercoagulability
  • outcomes
  • thromboelastography
  • transfusion requirements
  • trauma

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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    Branco, B. C., Inaba, K., Ives, C., Okoye, O., Shulman, I., David, J. S., Schöchl, H., Rhee, P., & Demetriades, D. (2014). Thromboelastogram evaluation of the impact of hypercoagulability in trauma patients. Shock, 41(3), 200-207. https://doi.org/10.1097/SHK.0000000000000109