Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan, W. M. Coplin, A. N. Al-Sadat, K. J. McAllen, L. H. Schwamm, L. R. Wechsler, Stella Kidwell, J. L. Saver, S. Starkman, Y. P. Gobin, G. Duckwiler, M. Krueger, G. Rordorf, J. P. Broderick, G. E. Tietjen, S. R. Levine

Research output: Contribution to journalArticle

88 Scopus citations


The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
Issue number5
Publication statusPublished - Mar 2006
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Murugappan, A., Coplin, W. M., Al-Sadat, A. N., McAllen, K. J., Schwamm, L. H., Wechsler, L. R., ... Levine, S. R. (2006). Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology, 66(5), 768-770.