Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan, W. M. Coplin, A. N. Al-Sadat, K. J. McAllen, L. H. Schwamm, L. R. Wechsler, C. S. Kidwell, J. L. Saver, S. Starkman, Y. P. Gobin, G. Duckwiler, M. Krueger, G. Rordorf, J. P. Broderick, G. E. Tietjen, S. R. Levine

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
JournalNeurology
Volume66
Issue number5
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Murugappan, A., Coplin, W. M., Al-Sadat, A. N., McAllen, K. J., Schwamm, L. H., Wechsler, L. R., Kidwell, C. S., Saver, J. L., Starkman, S., Gobin, Y. P., Duckwiler, G., Krueger, M., Rordorf, G., Broderick, J. P., Tietjen, G. E., & Levine, S. R. (2006). Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology, 66(5), 768-770. https://doi.org/10.1212/01.wnl.0000201272.90216.15