Thrombus formation patterns in the HeartMate II ventricular assist device: Clinical observations can be predicted by numerical simulations

Wei Che Chiu, Marvin J Slepian, Danny Bluestein

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Postimplant device thrombosis remains a life-threatening complication and limitation of continuous-flow ventricular assist devices (VADs). Using advanced computational fluid dynamic (CFD) simulations, we successfully depicted various flow patterns, recirculation zones, and stagnant platelet trajectories which promote thrombus formation and observed that they matched actual thrombus formation patterns observed in Thoratec HeartMate II VADs explanted from patients with pump thrombosis. Previously, these small eddies could not be captured by either digital particle image velocimetry or CFD due to insufficient resolution. Our study successfully demonstrated the potential capability of advanced CFD to be adopted for device optimization, leading to enhanced safety and efficacy of VADs for long-term destination therapy.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalASAIO Journal
Volume60
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Heart-Assist Devices
Computational fluid dynamics
Thrombosis
Hydrodynamics
Computer simulation
Platelets
Equipment and Supplies
Velocity measurement
Flow patterns
Rheology
Trajectories
Pumps
Blood Platelets
Safety
Therapeutics

Keywords

  • CFD
  • HeartMate II
  • Thrombosis
  • VAD

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Thrombus formation patterns in the HeartMate II ventricular assist device : Clinical observations can be predicted by numerical simulations. / Chiu, Wei Che; Slepian, Marvin J; Bluestein, Danny.

In: ASAIO Journal, Vol. 60, No. 2, 2014, p. 237-240.

Research output: Contribution to journalArticle

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