Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla

Initial results

Kambiz Nael, Henrik J. Michaely, Pablo Villablanca, Noriko Salamon, Gerhard Laub, J. Paul Finn

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 × 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 × 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by κ statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (κ =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 × 1 mm) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.

Original languageEnglish (US)
Pages (from-to)116-124
Number of pages9
JournalInvestigative Radiology
Volume41
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Magnetic Resonance Angiography
Neck
Head
Magnetic Resonance Imaging
gadodiamide
Pathologic Constriction
Subclavian Steal Syndrome
Cerebrovascular Disorders
Observer Variation
Signal-To-Noise Ratio
Nonparametric Statistics
Fistula
Aneurysm
Volunteers
Anatomy
Arteries
Confidence Intervals
Injections

Keywords

  • 3.0 Tesla
  • Carotid arteries
  • Echo-sharing
  • Head and neck MRA
  • High magnetic field
  • Parallel imaging
  • Time-resolved MRA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla : Initial results. / Nael, Kambiz; Michaely, Henrik J.; Villablanca, Pablo; Salamon, Noriko; Laub, Gerhard; Finn, J. Paul.

In: Investigative Radiology, Vol. 41, No. 2, 02.2006, p. 116-124.

Research output: Contribution to journalArticle

Nael, Kambiz ; Michaely, Henrik J. ; Villablanca, Pablo ; Salamon, Noriko ; Laub, Gerhard ; Finn, J. Paul. / Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla : Initial results. In: Investigative Radiology. 2006 ; Vol. 41, No. 2. pp. 116-124.
@article{daa260d6069342818f07cbcdc9a153b1,
title = "Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla: Initial results",
abstract = "OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 × 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 × 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by κ statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (κ =0.89; 95{\%} confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 × 1 mm) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.",
keywords = "3.0 Tesla, Carotid arteries, Echo-sharing, Head and neck MRA, High magnetic field, Parallel imaging, Time-resolved MRA",
author = "Kambiz Nael and Michaely, {Henrik J.} and Pablo Villablanca and Noriko Salamon and Gerhard Laub and Finn, {J. Paul}",
year = "2006",
month = "2",
doi = "10.1097/01.rli.0000192416.19801.ca",
language = "English (US)",
volume = "41",
pages = "116--124",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla

T2 - Initial results

AU - Nael, Kambiz

AU - Michaely, Henrik J.

AU - Villablanca, Pablo

AU - Salamon, Noriko

AU - Laub, Gerhard

AU - Finn, J. Paul

PY - 2006/2

Y1 - 2006/2

N2 - OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 × 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 × 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by κ statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (κ =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 × 1 mm) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.

AB - OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 × 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 × 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by κ statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (κ =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 × 1 mm) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.

KW - 3.0 Tesla

KW - Carotid arteries

KW - Echo-sharing

KW - Head and neck MRA

KW - High magnetic field

KW - Parallel imaging

KW - Time-resolved MRA

UR - http://www.scopus.com/inward/record.url?scp=33646353706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646353706&partnerID=8YFLogxK

U2 - 10.1097/01.rli.0000192416.19801.ca

DO - 10.1097/01.rli.0000192416.19801.ca

M3 - Article

VL - 41

SP - 116

EP - 124

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 2

ER -