Tissue engineering a bioartificial pancreas based on transformed endocrine cells

Thanassis Sambanis, Klearchos K Papas, Evangelos Tziampazis, Robert C. Long, Ioannis Constantinidis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages211
Number of pages1
Volume29
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

Fingerprint

Insulin
Alginate
Tissue engineering
Cells
Medical problems
Glucose
Calcium
Availability
Tissue
Energy Metabolism

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sambanis, T., Papas, K. K., Tziampazis, E., Long, R. C., & Constantinidis, I. (1995). Tissue engineering a bioartificial pancreas based on transformed endocrine cells. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 29, pp. 211). ASME.

Tissue engineering a bioartificial pancreas based on transformed endocrine cells. / Sambanis, Thanassis; Papas, Klearchos K; Tziampazis, Evangelos; Long, Robert C.; Constantinidis, Ioannis.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29 ASME, 1995. p. 211.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sambanis, T, Papas, KK, Tziampazis, E, Long, RC & Constantinidis, I 1995, Tissue engineering a bioartificial pancreas based on transformed endocrine cells. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 29, ASME, pp. 211, Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, 6/28/95.
Sambanis T, Papas KK, Tziampazis E, Long RC, Constantinidis I. Tissue engineering a bioartificial pancreas based on transformed endocrine cells. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29. ASME. 1995. p. 211
Sambanis, Thanassis ; Papas, Klearchos K ; Tziampazis, Evangelos ; Long, Robert C. ; Constantinidis, Ioannis. / Tissue engineering a bioartificial pancreas based on transformed endocrine cells. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29 ASME, 1995. pp. 211
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