Titin: An endosarcomeric protein that modulates myocardial stiffness in DCM

Yiming Wu, Siegfried LaBeit, Martin M. Lewinter, Hendrikus "Henk" Granzier

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Titin is the third myofilament of the cardiac muscle sarcomere, with a single molecule spanning the half sarcomere. Titin contains a molecular spring segment that generates passive force in sarcomeres stretched above the slack length and restoring forces in sarcomeres shortened below this length. The roles of titin in heart disease remain to be established. In this work we review recent developments in the understanding of titin's role in cardiac muscle. We focus on both short-term and long-term modulation of titin-based muscle stiffness, as well as on the recently discovered interplay between titin and actomysoin interaction, suggesting a possible role for titin in the Frank-Starling mechanism of the heart. Finally, we present evidence that suggests that titin plays a role in elevating passive stiffness of myocardium of dilated cardiomyopathy (DCM) hearts, via alterations in titin isoform expression.

Original languageEnglish (US)
JournalJournal of Cardiac Failure
Volume8
Issue number6 SUPPL.
DOIs
StatePublished - Dec 2002
Externally publishedYes

Fingerprint

Connectin
Dilated Cardiomyopathy
Sarcomeres
Proteins
Myocardium
Starlings
Myofibrils
Heart Diseases
Protein Isoforms
Muscles

Keywords

  • Cardiomyopathy
  • Diastole
  • Length-dependent activation
  • Myocardium
  • Phosphorylation
  • Titin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Titin : An endosarcomeric protein that modulates myocardial stiffness in DCM. / Wu, Yiming; LaBeit, Siegfried; Lewinter, Martin M.; Granzier, Hendrikus "Henk".

In: Journal of Cardiac Failure, Vol. 8, No. 6 SUPPL., 12.2002.

Research output: Contribution to journalArticle

Wu, Yiming ; LaBeit, Siegfried ; Lewinter, Martin M. ; Granzier, Hendrikus "Henk". / Titin : An endosarcomeric protein that modulates myocardial stiffness in DCM. In: Journal of Cardiac Failure. 2002 ; Vol. 8, No. 6 SUPPL.
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