Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Henk Granzier, Dietmar Labeit, Yiming Wu, Siegfried Labeit

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.

Original languageEnglish (US)
Pages (from-to)457-471
Number of pages15
JournalJournal of Muscle Research and Cell Motility
Volume23
Issue number5-6
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cell Biology

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