Tolerance to δ9-THC in adult rats with differential δ9-THC exposure when immature or during early adulthood

C. Barnes, P. A. Fried

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Tolerance to δ9-tetrahydrocannabinol (THC) was examined in 96 rats, 48 of which were immature (30 days) at the start of the study and 48 of which were adults (90 days). For both age groups the treatments consisted of three phases and during each phase, lasting at least twenty days, animals received either THC or a control drug. Behavioral measures were taken during the third phase and, at the end of the study, weights of various organs were determined. The results revealed that degrees of tolerance exist and that the age of the subject at the time of initial chronic THC experience interacts with the later development of tolerance to the drug. In addition, heart and brain weights were reduced in those subjects receiving chronic THC injections while immature.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalPsychopharmacologia
Volume34
Issue number3
DOIs
StatePublished - Sep 1 1974
Externally publishedYes

Keywords

  • Age Effects
  • Tolerance
  • δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology

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