Tolerance to δ9-tetrahydrocannabinol (THC) was examined in 96 rats, 48 of which were immature (30 days) at the start of the study and 48 of which were adults (90 days). For both age groups the treatments consisted of three phases and during each phase, lasting at least twenty days, animals received either THC or a control drug. Behavioral measures were taken during the third phase and, at the end of the study, weights of various organs were determined. The results revealed that degrees of tolerance exist and that the age of the subject at the time of initial chronic THC experience interacts with the later development of tolerance to the drug. In addition, heart and brain weights were reduced in those subjects receiving chronic THC injections while immature.
- Age Effects
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