Toll-like receptor 6 gene (TLR6)

Single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

K. Tantisira, Walter Klimecki, R. Lazarus, L. J. Palmer, B. A. Raby, D. J. Kwiatkowski, E. Silverman, Donata Vercelli, Fernando Martinez, S. T. Weiss

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Toll-like receptor 6 (TLR6) is one of a series of highly conserved innate immune receptors. We resequenced TLR6 in DNA samples from 24 African Americans, 23 European Americans, and 24 Hispanic Americans, identifying 53 SNPs, 22 with an allele frequency > 5%. Significant differences in SNP frequencies among the three populations were noted. In all, 11 SNPs caused amino-acid changes, including one with a frequency > 5% in all three populations. Utilizing this SNP (Ser249Pro), we performed exploratory nested case - control disease-association studies, including one involving 56 African Americans with asthma and 93 African American controls. The minor allele of this SNP was associated with decreased risk for asthma (odds ratio 0.38, 95% CI 0.16 - 0.87, P=0.01), an effect consistent with the known biology of the toll-like receptors. Although replication of this finding in other, larger samples is needed, variation in TLR6 may have relevance to the pathogenesis of immunologically mediated diseases.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalGenes and Immunity
Volume5
Issue number5
DOIs
StatePublished - Aug 2004

Fingerprint

Toll-Like Receptor 6
Single Nucleotide Polymorphism
Asthma
African Americans
Genes
Toll-Like Receptors
Hispanic Americans
Gene Frequency
Population
Alleles
Odds Ratio
Amino Acids
DNA

Keywords

  • Asthma
  • Innate immunity
  • SNP
  • TLR6
  • Toll-like receptor 6

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Toll-like receptor 6 gene (TLR6) : Single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. / Tantisira, K.; Klimecki, Walter; Lazarus, R.; Palmer, L. J.; Raby, B. A.; Kwiatkowski, D. J.; Silverman, E.; Vercelli, Donata; Martinez, Fernando; Weiss, S. T.

In: Genes and Immunity, Vol. 5, No. 5, 08.2004, p. 343-346.

Research output: Contribution to journalArticle

Tantisira, K. ; Klimecki, Walter ; Lazarus, R. ; Palmer, L. J. ; Raby, B. A. ; Kwiatkowski, D. J. ; Silverman, E. ; Vercelli, Donata ; Martinez, Fernando ; Weiss, S. T. / Toll-like receptor 6 gene (TLR6) : Single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. In: Genes and Immunity. 2004 ; Vol. 5, No. 5. pp. 343-346.
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