Tomographic small-animal imaging using a high-resolution semiconductor camera

G. A. Kastis, M. C. Wu, S. J. Balzer, D. W. Wilson, L. R. Furenlid, G. Stevenson, H. B. Barber, H. H. Barrett, J. M. Woolfenden, P. Kelly, M. Appleby

Research output: Contribution to conferencePaper

3 Scopus citations


We have developed a high-resolution, compact semiconductor camera for nuclear medicine applications. The modular unit has been used to obtain tomographic images of phantoms and mice. The system consists of a 64 × 64 CdZnTe detector array and a parallel-hole tungsten collimator mounted inside a 17 cm × 5.3 cm × 3.7 cm tungsten-aluminum housing. The detector is a 2.5 cm × 2.5 cm × 0.15 cm slab of CdZnTe connected to a 64 × 64 multiplexer readout via indium-bump bonding. The collimator is 7mm thick, with a 0.38 mm pitch that matches the detector pixel pitch. We obtained a series of projections by rotating the object in front of the camera. The axis of rotation was vertical and about 1.5 cm away from the collimator face. Mouse holders were made out of acrylic plastic tubing to facilitate rotation and the administration of gas anesthetic. Acquisition times were varied from 60 sec to 90 sec per image for a total of 60 projections at an equal spacing of 6 degrees between projections. We present tomographic images of a line phantom and mouse bone scan and assess the properties of the system. The reconstructed images demonstrate spatial resolution on the order of 1-21 mm.

Original languageEnglish (US)
StatePublished - Dec 1 2000
Event2000 IEEE Nuclear Science Symposium Conference Record - Lyon, France
Duration: Oct 15 2000Oct 20 2000


Other2000 IEEE Nuclear Science Symposium Conference Record


ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Kastis, G. A., Wu, M. C., Balzer, S. J., Wilson, D. W., Furenlid, L. R., Stevenson, G., Barber, H. B., Barrett, H. H., Woolfenden, J. M., Kelly, P., & Appleby, M. (2000). Tomographic small-animal imaging using a high-resolution semiconductor camera. 21/31-21/35. Paper presented at 2000 IEEE Nuclear Science Symposium Conference Record, Lyon, France.