Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults

Christopher Bell, Douglas R. Seals, Mary Beth Monroe, Danielle S. Day, Linda F. Shapiro, David G Johnson, Pamela Parker Jones

Research output: Contribution to journalArticle

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Abstract

We recently demonstrated in young adult humans that the sympathetic nervous system contributes to the control of resting metabolic rate via tonic β-adrenergic receptor stimulation. In the present follow-up study we determined the respective effects of age, habitual exercise status, and sex on this regulatory mechanism. Resting metabolic rate (ventilated hood, indirect calorimetry) was determined in 55 healthy sedentary or endurance exercise-trained adults, aged 18-35 or 60-75 yr (29 men and 26 women), before (baseline) and during the infusion of either a nonselective β-adrenergic receptor antagonist (propranolol) or saline (control). Relative to baseline values, during β-adrenergic receptor antagonism resting metabolic rate adjusted for fat-free mass was reduced to a lesser extent in older (mean ± SE, -130 ± 46 kJ/d) compared with young (-297 ± 46) adults, sedentary (-151 ± 50) compared with endurance exercise-trained (-268 ± 46) adults, and women (-105 ± 33) compared with men (-318 ± 50; all P < 0.01). Reductions in resting metabolic rate during β-adrenergic receptor antagonism were positively related to higher baseline resting metabolic rate and plasma catecholamine concentrations and negatively related to adiposity (all P < 0.05). Resting metabolic rate was unchanged in response to saline control in all groups. These results provide experimental support for the hypothesis that aging, sedentary living, and female sex are associated with attenuated sympathetic nervous system support of resting metabolic rate in healthy adult humans.

Original languageEnglish (US)
Pages (from-to)4440-4444
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number9
DOIs
StatePublished - 2001

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Sedentary Lifestyle
Basal Metabolism
Adrenergic Receptors
Neurology
Durability
Adrenergic Antagonists
Calorimetry
Propranolol
Sympathetic Nervous System
Exercise
Catecholamines
Aging of materials
Fats
Plasmas
Indirect Calorimetry
Adiposity
Young Adult

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. / Bell, Christopher; Seals, Douglas R.; Monroe, Mary Beth; Day, Danielle S.; Shapiro, Linda F.; Johnson, David G; Jones, Pamela Parker.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 9, 2001, p. 4440-4444.

Research output: Contribution to journalArticle

Bell, Christopher ; Seals, Douglas R. ; Monroe, Mary Beth ; Day, Danielle S. ; Shapiro, Linda F. ; Johnson, David G ; Jones, Pamela Parker. / Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 9. pp. 4440-4444.
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