Toward a model for local drug delivery in abdominal aortic aneurysms

Jonathan P Vande Geest, Bruce R. Simon, Ariane Mortazavi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The formation of an abdominal aortic aneurysm (AAA) may eventually result in rupture, an event associated with a 50% mortality rate. This work represents a first step toward improving current stress estimation techniques and local transport simulations in AAA. Toward this aim, a computational parametric studywas performed on an axisymmetric cylindrical FEM of a 5 cm AAA with a 1.5 cm thick intraluminal thrombus (ILT). Both the AAA wall and ILT were modeled as porohyperelastic PHE materials using estimated values of AAA wall and ILT permeability. While no values for AAA wall permeability could be found in the literature, the value of ILT permeability was taken from a previous investigation by Adolph et al.7 Peak stresses, fluid velocities, and local pore pressure values within the ILT and wall were recorded and analyzed as a function of the cardiac cycle. While peak wall stress values for the PHE models did not largely differ from corresponding solid finite element simulations (186.2 N/cm2 vs. 186.5 N/cm2), the stress in the abluminal region of the ILT increased by 17.4% (7.7 N/cm2 vs. 6.5 N/cm2). Pore pressure values were relatively constant through the ILT while there were significant pore pressure gradients present in the AAA wall. The magnitude of fluid velocities varied in magnitude and direction throughout the cardiac cycle with large fluctuations occurring on the luminal surface. The combination of the patient-specific PHE AAA FEMs with mass transport simulations will result in spatially and time-varying concentration distributions within AAA, which may benefit future pharmaceutical treatments of AAA.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages396-399
Number of pages4
Volume1085
DOIs
StatePublished - Nov 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1085
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Abdominal Aortic Aneurysm
Drug delivery
Pore pressure
Thrombosis
Pharmaceutical Preparations
Finite element method
Fluids
Permeability
Pressure gradient
Mass transfer
Pressure
Rupture
Mortality

Keywords

  • Aneurysm
  • Local drug delivery
  • Porohyperelasticity
  • Stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vande Geest, J. P., Simon, B. R., & Mortazavi, A. (2006). Toward a model for local drug delivery in abdominal aortic aneurysms. In Annals of the New York Academy of Sciences (Vol. 1085, pp. 396-399). (Annals of the New York Academy of Sciences; Vol. 1085). https://doi.org/10.1196/annals.1383.047

Toward a model for local drug delivery in abdominal aortic aneurysms. / Vande Geest, Jonathan P; Simon, Bruce R.; Mortazavi, Ariane.

Annals of the New York Academy of Sciences. Vol. 1085 2006. p. 396-399 (Annals of the New York Academy of Sciences; Vol. 1085).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vande Geest, JP, Simon, BR & Mortazavi, A 2006, Toward a model for local drug delivery in abdominal aortic aneurysms. in Annals of the New York Academy of Sciences. vol. 1085, Annals of the New York Academy of Sciences, vol. 1085, pp. 396-399. https://doi.org/10.1196/annals.1383.047
Vande Geest JP, Simon BR, Mortazavi A. Toward a model for local drug delivery in abdominal aortic aneurysms. In Annals of the New York Academy of Sciences. Vol. 1085. 2006. p. 396-399. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1383.047
Vande Geest, Jonathan P ; Simon, Bruce R. ; Mortazavi, Ariane. / Toward a model for local drug delivery in abdominal aortic aneurysms. Annals of the New York Academy of Sciences. Vol. 1085 2006. pp. 396-399 (Annals of the New York Academy of Sciences).
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