Toward maintaining the genome: DNA damage and replication checkpoints

Kara A. Nyberg, Rhett J. Michelson, Charles W. Putnam, Ted Weinert

Research output: Contribution to journalArticle

611 Citations (Scopus)

Abstract

DNA checkpoints play a significant role in cancer pathology, perhaps most notably in maintaining genome stability. This review summarizes the genetic and molecular mechanisms of checkpoint activation in response to DNA damage. The major checkpoint proteins common to all eukaryotes are identified and discussed, together with how the checkpoint proteins interact to induce arrest within each cell cycle phase. Also discussed are the molecular signals that activate checkpoint responses, including single-strand DNA, double-strand breaks, and aberrant replication forks. We address the connection between checkpoint proteins and damage repair mechanisms, how cells recover from an arrest response, and additional roles that checkpoint proteins play in DNA metabolism. Finally, the connection between checkpoint gene mutation and genomic instability is considered.

Original languageEnglish (US)
Pages (from-to)617-656
Number of pages40
JournalAnnual review of genetics.
Volume36
DOIs
StatePublished - 2002

Fingerprint

DNA Replication
DNA Damage
Genome
Genomic Instability
Proteins
Double-Stranded DNA Breaks
DNA
Eukaryota
Molecular Biology
Cell Cycle
Pathology
Mutation
Genes
Neoplasms

Keywords

  • ATM
  • BRCA1
  • Genomic instability
  • p53
  • Repair

ASJC Scopus subject areas

  • Genetics

Cite this

Toward maintaining the genome : DNA damage and replication checkpoints. / Nyberg, Kara A.; Michelson, Rhett J.; Putnam, Charles W.; Weinert, Ted.

In: Annual review of genetics., Vol. 36, 2002, p. 617-656.

Research output: Contribution to journalArticle

Nyberg, Kara A. ; Michelson, Rhett J. ; Putnam, Charles W. ; Weinert, Ted. / Toward maintaining the genome : DNA damage and replication checkpoints. In: Annual review of genetics. 2002 ; Vol. 36. pp. 617-656.
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