Toward optimization of a novel trileaflet polymeric prosthetic heart valve via device thrombogenicity emulation

Thomas E. Claiborne, Michalis Xenos, Jawaad Sheriff, Wei Che Chiu, Joao Soares, Yared Alemu, Shikha Gupta, Stefan Judex, Marvin J. Slepian, Danny Bluestein

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Aortic stenosis is the most prevalent and life-threatening form of valvular heart disease. It is primarily treated via open-heart surgical valve replacement with either a tissue or a mechanical prosthetic heart valve (PHV), each prone to degradation and thrombosis, respectively. Polymeric PHVs may be optimized to eliminate these complications, and they may be more suitable for the new transcatheter aortic valve replacement procedure and in devices like the total artificial heart. However, the development of polymer PHVs has been hampered by persistent in vivo calcification, degradation, and thrombosis. To address these issues, we have developed a novel surgically implantable polymer PHV composed of a new thermoset polyolefin called cross-linked poly(styrene-block-isobutylene-block-styrene), or xSIBS, in which key parameters were optimized for superior functionality via our device thrombogenicity emulation methodology. In this parametric study, we compared our homogeneous optimized polcymer PHV to a prior composite polymer PHV and to a benchmark tissue valve. Our results show significantly improved hemodynamics and reduced thrombogenicity in the optimized polymer PHV compared to the other valves. These results indicate that our new design may not require anticoagulants and may be more durable than its predecessor, and validate the improvement, toward optimization, of this novel polymeric PHV design.

Original languageEnglish (US)
Pages (from-to)275-283
Number of pages9
JournalASAIO Journal
Volume59
Issue number3
DOIs
StatePublished - May 1 2013

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Keywords

  • aortic stenosis
  • artificial heart
  • numerical analysis
  • platelet activation
  • transcatheter

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Claiborne, T. E., Xenos, M., Sheriff, J., Chiu, W. C., Soares, J., Alemu, Y., Gupta, S., Judex, S., Slepian, M. J., & Bluestein, D. (2013). Toward optimization of a novel trileaflet polymeric prosthetic heart valve via device thrombogenicity emulation. ASAIO Journal, 59(3), 275-283. https://doi.org/10.1097/MAT.0b013e31828e4d80