Toward the development of miniaturized imaging systems for detection of pre-cancer

Michael R. Descour, Ari H.O. Kärkkäinen, Jeremy D. Rogers, Chen Liang, Ronald S. Weinstein, Juha T. Rantala, Bahattin Kilic, Erdogan Madenci, Rebecca R. Richards-Kortum, Eric V. Anslyn, Russell D. Dupuis, Randy J. Schul, Christi G. Willison, Chris P. Tigges

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalIEEE Journal of Quantum Electronics
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2002

Keywords

  • Biomedical imaging
  • Biomedical microscopy
  • Hybrid sol-gel materials
  • Microassembly
  • Microoptics
  • Photolithography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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    Descour, M. R., Kärkkäinen, A. H. O., Rogers, J. D., Liang, C., Weinstein, R. S., Rantala, J. T., Kilic, B., Madenci, E., Richards-Kortum, R. R., Anslyn, E. V., Dupuis, R. D., Schul, R. J., Willison, C. G., & Tigges, C. P. (2002). Toward the development of miniaturized imaging systems for detection of pre-cancer. IEEE Journal of Quantum Electronics, 38(2), 122-130. https://doi.org/10.1109/3.980264