Toward the development of miniaturized imaging systems for detection of pre-cancer

Michael R. Descour, Ari H O Kärkkäinen, Jeremy D. Rogers, Chen Liang, Ronald S Weinstein, Juha T. Rantala, Bahattin Kilic, Erdogan Madenci, Rebecca R. Richards-Kortum, Eric V. Anslyn, Russell D. Dupuis, Randy J. Schul, Christi G. Willison, Chris P. Tigges

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA = 0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalIEEE Journal of Quantum Electronics
Volume38
Issue number2
DOIs
StatePublished - Feb 2002

Fingerprint

Imaging systems
Microscopes
Optical devices
cancer
microscopes
Silicon
silicon
Medical imaging
mounting
Mountings
slots
Optics
surface roughness
assembly
Surface roughness
Fluorescence
alignment
optics
Glass
fluorescence

Keywords

  • Biomedical imaging
  • Biomedical microscopy
  • Hybrid sol-gel materials
  • Microassembly
  • Microoptics
  • Photolithography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Physics and Astronomy (miscellaneous)

Cite this

Descour, M. R., Kärkkäinen, A. H. O., Rogers, J. D., Liang, C., Weinstein, R. S., Rantala, J. T., ... Tigges, C. P. (2002). Toward the development of miniaturized imaging systems for detection of pre-cancer. IEEE Journal of Quantum Electronics, 38(2), 122-130. https://doi.org/10.1109/3.980264

Toward the development of miniaturized imaging systems for detection of pre-cancer. / Descour, Michael R.; Kärkkäinen, Ari H O; Rogers, Jeremy D.; Liang, Chen; Weinstein, Ronald S; Rantala, Juha T.; Kilic, Bahattin; Madenci, Erdogan; Richards-Kortum, Rebecca R.; Anslyn, Eric V.; Dupuis, Russell D.; Schul, Randy J.; Willison, Christi G.; Tigges, Chris P.

In: IEEE Journal of Quantum Electronics, Vol. 38, No. 2, 02.2002, p. 122-130.

Research output: Contribution to journalArticle

Descour, MR, Kärkkäinen, AHO, Rogers, JD, Liang, C, Weinstein, RS, Rantala, JT, Kilic, B, Madenci, E, Richards-Kortum, RR, Anslyn, EV, Dupuis, RD, Schul, RJ, Willison, CG & Tigges, CP 2002, 'Toward the development of miniaturized imaging systems for detection of pre-cancer', IEEE Journal of Quantum Electronics, vol. 38, no. 2, pp. 122-130. https://doi.org/10.1109/3.980264
Descour, Michael R. ; Kärkkäinen, Ari H O ; Rogers, Jeremy D. ; Liang, Chen ; Weinstein, Ronald S ; Rantala, Juha T. ; Kilic, Bahattin ; Madenci, Erdogan ; Richards-Kortum, Rebecca R. ; Anslyn, Eric V. ; Dupuis, Russell D. ; Schul, Randy J. ; Willison, Christi G. ; Tigges, Chris P. / Toward the development of miniaturized imaging systems for detection of pre-cancer. In: IEEE Journal of Quantum Electronics. 2002 ; Vol. 38, No. 2. pp. 122-130.
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