Towards a multiphysics model for tumor response to combined-hyperthermia-radiotherapy treatment

Japan K. Patel, Richard Vasques, Barry D. Ganapol

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall treatment. In addition to directly killing tumor cells, tumor heating amends several parameters within the tumor microenvironment. This leads to radiosensitization, which improves the performance of radiotherapy while reducing the side-effects of excess radiation in the surrounding normal tissue. Existing tools to model this kind of treatment consider each of the physics separately. The model presented in this paper accounts for the synergy between hyperthermia and radiotherapy providing a more realistic and holistic approach to simulate CHR treatment. Our model couples radiation transport and heat-transfer with cell population dynamics.

Original languageEnglish (US)
Title of host publicationInternational Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019
PublisherAmerican Nuclear Society
Pages1002-1011
Number of pages10
ISBN (Electronic)9780894487699
StatePublished - Jan 1 2019
Event2019 International Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019 - Portland, United States
Duration: Aug 25 2019Aug 29 2019

Publication series

NameInternational Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019

Conference

Conference2019 International Conference on Mathematics and Computational Methods Applied to Nuclear Science and Engineering, M and C 2019
CountryUnited States
CityPortland
Period8/25/198/29/19

Keywords

  • Hyperthermia
  • Multiphysics
  • Radiotherapy
  • Transport
  • Tumor dynamics

ASJC Scopus subject areas

  • Applied Mathematics
  • Nuclear Energy and Engineering

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